BALTIMORE – Patients who have recurrent adrenocortical carcinoma appear to have one option to increase their survival: surgery that includes complete tumor resection – but it may a viable path only…

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Publication date: Available online 7 July 2018Source: Journal of Visceral SurgeryAuthor(s): F. Prunel, S. Bonnet, S. Gaujoux, B. Dousset

Conclusions: ACC continues to be a rare malignancy in the United States. However, most cases continue to be diagnosed only in advanced stages and are associated with poor survival. These findings underline the need for specific diagnostics tools with new and more effective treatment options.
PMID: 29977421 [PubMed]

Source: Clin Med ResCategory: Research Authors: Tags: J Clin Med Res Source Type: research

Publication date: Available online 4 July 2018Source: The Kaohsiung Journal of Medical SciencesAuthor(s): Mongkontida Umphonsathien, Panudda Srichomkwun, Patinut Buranasupkajorn, Thiti Snabboon

Publication date: Available online 20 February 2018Source: Molecular and Cellular EndocrinologyAuthor(s): Carmen Ruggiero, Mabrouka Doghman-Bouguerra, Cyril Ronco, Rachid Benhida, Stéphane Rocchi, Enzo LalliAbstractMany types of cancer cells present constitutively activated ER stress pathways because of their significant burden of misfolded proteins coded by mutated and rearranged genes. Further increase of ER stress by pharmacological intervention may shift the balance towards cell death and can be exploited therapeutically. Recent studies have shown that an important component in the mechanism of action of mitotan…

In conclusion, our data extend previous findings in non-human systems to implicate the M3 receptor as the dominant muscarinic receptor in the human adrenal cortex.

Publication date: Available online 4 July 2018 Source:The Kaohsiung Journal of Medical Sciences Author(s): Mongkontida Umphonsathien, Panudda Srichomkwun, Patinut Buranasupkajorn, Thiti Snabboon

Background: The adjuvant use of mitotane on adrenocortical carcinoma (ACC) has always been in controversy. We aimed to assess the prognostic benefits of adjuvant mitotane after resection of ACC in patients without distant metastasis.
Methods: The PubMed, WoS, Embase, and Cochrane Library databases were systematically searched. Recurrence-free survival (RFS) and overall survival (OS) were adopted as measurements. A meta-analysis was conducted based on hazard ratio (HR) with 95% confidence interval (CI). A study was included only if the enrolled patients underwent resection of ACC without adjuvant chem…

Source: Biomed ResCategory: Research Authors: Tags: Biomed Res Int Source Type: research

CONCLUSIONS: Nowadays, predictive markers for the response of target-IGF therapy are missing and further studies which investigate new molecular markers and evaluate the entire IGF receptors, including the IR, are urgently needed.
PMID: 29963827 [PubMed – as supplied by publisher]

Source: Minerva EndocrinologicaCategory: Endocrinology Tags: Minerva Endocrinol Source Type: research

In conclusion, sex, BMI and age are associated with the incidence and survival rates for cancers. These results could be used to supplement precision and personalized medicine.
PMID: 29956810 [PubMed – as supplied by publisher]

Source: Oncology ReportsCategory: Cancer & Oncology Tags: Oncol Rep Source Type: research

: Metastatic adrenocortical carcinoma (ACC) is an aggressive malignancy with a poor prognosis and limited therapeutic options. A subset of ACC is due to Lynch syndrome, an inherited tumor syndrome resulting from germline mutations in mismatch repair (MMR) genes. It has been demonstrated that several cancers characterized by MMR-deficiency are sensitive to immune checkpoint inhibitors that target PD-1. Here, we provide the first report of PD-1 blockade with pembrolizumab in a patient with Lynch syndrome and progressive cortisol-secreting metastatic ACC.

Source: Seminars in OncologyCategory: Cancer & Oncology Authors: Source Type: research

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