(St. Jude Children’s Research Hospital) St. Jude Children’s Research Hospital research related to survivorship and the pediatric solid tumors neuroblastoma, adrenocortical carcinoma and nasopharyngeal carcinoma will be presented at the 2016 American Society of Clinical Oncology Annual Meeting. The five-day event begins June 3 in Chicago.

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Publication date: Available online 7 July 2018Source: Inorganica Chimica ActaAuthor(s): Selma Akcha, Santiago Gómez-Ruiz, Safia Kellou-Tairi, Luis Lezama, Frank Blanco Pérez, Ouassini Benali-BaitichAbstractOur work describes the synthesis, the complexation and the characterization of a cobalt(II) complex with a 5-pyrazolone ligand carrying a thioamide group on N1 position. The study of the complexation in solution allowed the determination of the stability constants of the complex and the distribution of the species involving Co(II) over the whole pH-range. The solid cobalt(II) complex has then been synthesiz…

Publication date: 20 October 2018Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects, Volume 555Author(s): Marek Piotrowski, Danuta Jantas, Monika Leśkiewicz, Krzysztof Szczepanowicz, Piotr Warszyński, Władysław LasońAbstractExperimental data have demonstrated the neuroprotective potential of cyclosporine A (CsA), however, its clinical usage as neuroprotectant is limited due to poor blood-brain barrier permeability and potential peripheral and central toxicity. In order to overcome these limitations, the nanoparticulate CsA delivery technology has been recently proposed to improve CsA immunosuppre…

Yoo SM, Fiano R, D’Amico AV, Nickols NG, Aronson WJ, Sadeghi A, Greco SC, Deville C, McNutt T, DeWeese TL, Reiter RE, Said JW, Steinberg ML, Horwitz EM, Kupelian PA, King CR, Kishan AU
PURPOSE: Gleason score (GS) 10 disease is the most aggressive form of clinically localized prostate adenocarcinoma (PCa). The long-term clinical outcomes and overall prognosis of patients presenting with GS 10 PCa are largely unknown because of its rarity.
METHODS AND MATERIALS: The study included 112 patients with biopsy-determined GS 10 PCa who received treatment with radical prostatectomy (RP, n = 26), external bea…

Source: Ann OncolCategory: Cancer & Oncology Authors: Tags: Int J Radiat Oncol Biol Phys Source Type: research
Source: BMJ CommentsCategory: General Medicine Source Type: forums

Publication date: Available online 8 July 2018Source: SteroidsAuthor(s): Alexander M. Scherbakov, Igor V. Zavarzin, Svetlana K. Vorontsova, Alakananda Hajra, Olga E. Andreeva, Anton V. Yadykov, Inna S. Levina, Yulia A. Volkova, Valerii Z. ShirinianAbstractNovel benzylidenes (chalcones) of the 16-dehydroprogesterone series were characterized and their antitumor activity against two breast cancer cell lines was evaluated. Benzylidenes exhibit significant antiproliferative effect on cells and inhibit cell growth in hormone-dependent MCF-7 and hormone-independent MDA-MB-231 breast cancer cell lines. Compound 3d exhibits the hi…

Source: SteroidsCategory: Drugs & Pharmacology Source Type: research

Publication date: Available online 8 July 2018Source: International Journal of PharmaceuticsAuthor(s): Shubhangi Mahajan, Abhimanyu Patharkar, Kaushik Kuche, Rahul Maheshwari, Pran Kishore Deb, Kiran Kalia, Rakesh K. TekadeAbstractIn recent time, carbon nanotubes (CNTs) have gained vital importance for pharmaceutical formulation scientist for delivering drugs and genes, owing to their excellent surface properties. For example, their aspect ratio is thought to be responsible for their excellent cell penetration aptitude; anisotropic conductivity/semi-conductivity along their axis is ideal for integration with nervous and mu…

Publication date: Available online 8 July 2018Source: Biochimica et Biophysica Acta (BBA) – Reviews on CancerAuthor(s): Mohit Kumar Jolly, Sendurai A. Mani, Herbert LevineAbstractMetastasis is the leading cause of mortality among cancer patients. Dissemination enabled by an epithelial-to-mesenchymal transition (EMT) of carcinoma cells has long been considered to be the predominant mechanism for carcinoma metastasis, based on overexpression studies of many EMT-inducing transcription factors. Individual CTCs – and a binary framework of EMT – have been long considered to be sufficient and necessary condition for m…

Conclusion: The combined measurement of both TFF1 and TFF3 mRNA level for differentiation of metastatic from nonmetastatic breast cancer gave 57.69% sensitivity and 83.3% specificity.
PMID: 29977293 [PubMed]

Source: Journal of OncologyCategory: Cancer & Oncology Tags: J Oncol Source Type: research

Authors: Martins D, Schmitt F
It is now widely accepted that the tumor microenvironment is a pathologically active niche that shapes tumor nature, evolution and response to treatment. Close interactions between cancer cells and stroma are known to regulate several cancer pathways and thus the determination of different tumor-stromal interactions could be an important step in invasiveness. The breast cancer microenvironment is a complex combination of several different cell types and molecules and a key contributor to tumor development and progression. The microenvironment includes fibroblasts, macrophages,…

CONCLUSIONS: Our study showed that overexpression of LINC01793 indicates the poor prognosis of gastric cancer patients. Therefore, LINC01793 may serve as a target for the diagnosis and treatment of gastric cancer.
PMID: 29978448 [PubMed – as supplied by publisher]

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