(Institute of Cancer Research) A major new analysis reveals the likely cause of most cases of childhood leukaemia, following more than a century of controversy about its origins.Professor Mel Greaves assessed the most comprehensive body of evidence ever collected on acute lymphoblastic leukaemia (ALL). He concludes the disease is caused through a two-step process of genetic mutation and exposure to infection that means it may be preventable with treatments to stimulate or ‘prime’ the immune system in infancy.
Publication date: August 2018Source: Cancer Genetics, Volumes 224–225Author(s): Μ. Αmpatzidou, S.I. Papadhimitriou, G. Paterakis, D. Pavlidis, Κ. Tsitsikas, I.V. Kostopoulos, V. Papadakis, G. Vassilopoulos, S. PolychronopoulouThe prognostic significance of the ETV6/RUNX1-fusion and of the accompanying aberrations is disputable; whether co-existing sub-clones are responsible for delayed MRD-clearance and thus, moderate outcome, remains to be clarified. We studied, in a paediatric cohort of 119 B-ALLs, the relation between the ETV6/RUNX1 aberration and the co-existing subclones with (a) presenting clinic…
Publication date: 14 May 2018Source: Cancer Cell, Volume 33, Issue 5Author(s): Junne Kamihara, Akiko ShimamuraIKZF1 plays an essential role in lymphopoiesis, and somatic IKZF1 variants in acute lymphoblastic leukemia (ALL) are associated with poor prognosis. In this issue of Cancer Cell, Churchman et al. add to the list of leukemia predisposition genes with the identification and characterization of germline IKZF1 variants in childhood ALL.
Publication date: 14 May 2018Source: Cancer Cell, Volume 33, Issue 5Author(s): Michelle L. Churchman, Maoxiang Qian, Geertruy te Kronnie, Ranran Zhang, Wenjian Yang, Hui Zhang, Tobia Lana, Paige Tedrick, Rebekah Baskin, Katherine Verbist, Jennifer L. Peters, Meenakshi Devidas, Eric Larsen, Ian M. Moore, Zhaohui Gu, Chunxu Qu, Hiroki Yoshihara, Shaina N. Porter, Shondra M. Pruett-Miller, Gang WuSummarySomatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia (ALL) and are associated with poor prognosis. Such alterations res…
Induction chemotherapy results in high remission rate in high risk (HR) and very high risk (VHR) childhood acute lymphoblastic leukemia (ALL), but is associated with significant morbidity [1,2]. HR B-ALL is defined as: white blood cell count (WBC) ≥50,000/µL or age ≥10 years (National Cancer Institute (NCI) criteria) at presentation, or/and central nervous system (CNS) positive leukemia, or testicular leukemia [3–5]. Patients who are>13 years or experience induction failures; and/or if the leukemia blasts harbor mixed-lineage leukemia gene (MLL) rearrangements or intrachromosomal amplification of chrom…
Publication date: October 2018 Source:Cancer Genetics, Volumes 226–227 Author(s): LB Baughn, MM Meredith, L Oseth, TA Smolarek, B Hirsch Acute lymphoblastic leukemia (ALL) represents the most common childhood malignancy. Although survival for pediatric B-ALL has approached 90%, variability in outcome among and within cytogenetically defined subgroups persists. While G-banding and fluorescence in situ hybridization (FISH) have been used to characterize leukemic clones, there is added value of chromosomal microarray and next generation sequencing in screening genome-wide for copy number aberrations, copy neutral loss …
Conclusions: We found that telomere attrition may be
related to the pathogenesis of childhood ALL, irrespective to TERT variants.
PMID: 29936725 [PubMed – in process]
International Journal of Cancer,Volume 0, Issue ja, -Not available-.
Acute lymphoblastic leukemia (ALL) represents the most common childhood malignancy. Although survival for pediatric B-ALL has approached 90%, variability in outcome among and within cytogenetically-defined subgroups persists. While G-banding and fluorescence in situ hybridization (FISH) have been used to characterize leukemic clones, there is added value of chromosomal microarray and next generation sequencing in screening genome-wide for copy number aberrations, copy neutral loss of heterozygosity and nucleotide variations.
This study was carried out on 75 patients with newly diagnosed ALL. Transferrin receptor-1 expression was analyzed on the bone marrow blasts by flow cytometry at time of diagnosis with positive CD71 expression is considered when ≥20% of malignant cells express this marker while negative expression is considered when
Conclusion: This study suggested that the polymorphisms in NR3C1 were not associated
with the development of ALL in children. N363S polymorphism was sensitive to glucocorticoids and it may contribute
to the glucose abnormality for these patients.
PMID: 29802709 [PubMed – in process]