Women with DES – related clear – cell adenocarcinoma had 27 – fold higher mortality at 10 to 34 years

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Microwave ablation is an effective and safe treatment technique for painful spinal metastases. Further studies may be helpful in determining the role of microwave ablation in locoregional control of metastases.

Source: American Journal of NeuroradiologyCategory: Radiology Authors: Tags: SPINE Source Type: research

AbstractIntroductionCurrently, neoadjuvant fluoropyrimidine-based chemoradiation followed by surgery is considered the standard of care for locally advanced rectal cancer. The current study aimed to investigate the predictive significance of mucinous histology on the pathologic complete response rate following neoadjuvant chemoradiation in locally advanced rectal cancer and to propose potential new treatment protocol for this specific histology.Material and MethodThis retrospective study was conducted on 403 patients with locally advanced (clinically T3 –4 and/or N1–2) rectal adenocarcinoma who had been treated…

Radiation therapy (XRT) is a standard treatment for prostate cancer (PCa). Although dose escalation increases local control, toxicity hampers further escalation. Broader improvement will be possible by the addition of adjuvant therapies, which can synergize with radiation and thus improve efficacy. We have identified a natural compound (Nexrutine, Nx) that inhibits the survival and growth of PCa cells in combination with radiation. Combination studies demonstrated strong interaction between Nx and radiation both in vitro in multiple PCa cell lines and in the Transgenic adenocarcinoma of mouse prostate (TRAMP) model.

Source: Cancer LettersCategory: Cancer & Oncology Authors: Tags: Original Articles Source Type: research

In this study, we investigated the antitumor and anti-metastasis efficacy of the selective FGFR1 inhibitor, PD173074 in PDAC. We used immunohistochemical and in situ hybridization analyses to demonstrate a strong correlation between FGFR1 amplification and/or expression and disease progression in PDAC patients. We showed that ALDHhigh (ALDH+) pancreatic cancer cells exhibited stem cell-like phenotype and expressed higher levels of FGFR1, Src, NF- κB, alongside stemness markers like Oct4 and Sox2, compared to their ALDHlow/null (ALDH −) counterparts, suggesting the preferential activation of the FGFR1/Src/NF-&ka…

Yoo SM, Fiano R, D’Amico AV, Nickols NG, Aronson WJ, Sadeghi A, Greco SC, Deville C, McNutt T, DeWeese TL, Reiter RE, Said JW, Steinberg ML, Horwitz EM, Kupelian PA, King CR, Kishan AU
PURPOSE: Gleason score (GS) 10 disease is the most aggressive form of clinically localized prostate adenocarcinoma (PCa). The long-term clinical outcomes and overall prognosis of patients presenting with GS 10 PCa are largely unknown because of its rarity.
METHODS AND MATERIALS: The study included 112 patients with biopsy-determined GS 10 PCa who received treatment with radical prostatectomy (RP, n = 26), external bea…

Source: Ann OncolCategory: Cancer & Oncology Authors: Tags: Int J Radiat Oncol Biol Phys Source Type: research

Publication date: Available online 7 July 2018Source: European Journal of Surgical OncologyAuthor(s): Leila Sisic, Thomas Schmidt, Susanne Blank, Henrik Nienhueser, Sara Dorr, Georg Martin Haag, Dirk Jäger, Thomas Bruckner, Beat P. Müller-Stich, Katja Ott, Markus W. Büchler, Alexis UlrichAbstractBackgroundPrognostic differences between pTN- and ypTN-categories and the prognostic accuracy of the 8th edition UICC-pTNM- and AJCC-ypTNM-staging-system for esophageal and gastric adenocarcinoma are unclear.MethodsWe retrospectively analyzed data of 740 patients with esophagogastric adenocarcinoma, who underwent cur…

Conclusion: Abnormality in urethrocystoscopy and bloody drainage during the physical exam were not found in this case, which is in contrast to the findings reported in literature. These unusual features add new knowledge about CCAU that deserves dissemination for improved CCAU diagnosis and management.
PMID: 29977425 [PubMed]

Source: Clin Med ResCategory: Research Authors: Tags: J Clin Med Res Source Type: research

Publication date: Available online 7 July 2018Source: SteroidsAuthor(s): Nguyen Hoai Nam, Ninh Thi Ngoc, Tran Thi Hong Hanh, Nguyen Xuan Cuong, Nguyen Van Thanh, Do Thi Thao, Do Cong Thung, Phan Van Kiem, Chau Van MinhAbstractUsing various chromatographic separations, seventeen steroids including seven new compounds, verrucorosteroids A−F (1−6) and verrucorosterone (7), were isolated from the Vietnamese gorgonian Verrucella corona. Their structures were elucidated by spectroscopic analysis, including HR QTOF MS, 1D and 2D NMR. Among isolates, verrucorosterone (7), 5,6α-epoxy-3β-hydroxy-(22E)-ergosta-…

Source: SteroidsCategory: Drugs & Pharmacology Source Type: research

Publication date: October 2018Source: Phytochemistry Letters, Volume 27Author(s): Ahri Bernie Djamen Mbeunkeu, Anatole Guy Blaise Azebaze, Michel Feussi Tala, Jean Emmanuel Mbosso Teinkela, Xavier Siwe Noundou, Rui Werner Maçedo Krause, Juliette Catherine Vardamides, Hartmut LaatschAbstractPhytochemical investigation of the methanol extracts of the twigs of Manniophyton fulvum has led to the isolation and characterization of three new pentacyclic triterpenoids, designated as 3α,28-dihydroxyfriedelan-1-one (1), manniotaraxerol A (3) and manniotaraxerol B (4), along with fourteen known compounds, 3α-hydrox…

Platinum-based therapy may improve survival in pancreatic ductal adenocarcinoma carrying deleterious germline mutations.JCO Precision Oncology

Source: Medscape Today HeadlinesCategory: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

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