Childhood acute leukaemia is caused by genetic mutations and a lack of childhood infection, scientists sayClean modern homes, antiseptic wipes and the understandable desire to protect small babies against any infection are all part of the cause of the most common form of childhood cancer, a leading expert has concluded after more than 30 years of research.Childhood acute leukaemia, says the highly respected Prof Mel Greaves, is nothing to do with power lines or nuclear fuel reprocessing stations. Nor is it to do with hot dogs and hamburgers or the Vatican radio mast, as have also been suggested. After the best part of a century of speculation, some of it with little basis in science, Greaves – who recently won the Royal Society’s prestigious Royal Medal – says the cancer is caused by a combination of genetic mutations and a lack of childhood infection.Continue reading…

Source: Guardian Unlimited ScienceCategory: Science Authors: Tags: Cancer Health Cancer research Medical research Science Society Children Source Type: news

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Publication date: August 2018Source: Cancer Genetics, Volumes 224–225Author(s): Μ. Αmpatzidou, S.I. Papadhimitriou, G. Paterakis, D. Pavlidis, Κ. Tsitsikas, I.V. Kostopoulos, V. Papadakis, G. Vassilopoulos, S. PolychronopoulouThe prognostic significance of the ETV6/RUNX1-fusion and of the accompanying aberrations is disputable; whether co-existing sub-clones are responsible for delayed MRD-clearance and thus, moderate outcome, remains to be clarified. We studied, in a paediatric cohort of 119 B-ALLs, the relation between the ETV6/RUNX1 aberration and the co-existing subclones with (a) presenting clinic…

Source: Cancer GeneticsCategory: Cancer & Oncology Source Type: research

ConclusionsSimilar to the population trend, mortality risk across sex, age at diagnosis, and most AML subtypes was lower in England. Survival outcome for AML with and without maturation in England was better than the population trend, while that for AML inv(16) was worse. Our findings suggest that future etiologic and policy research may uncover the underlying mechanisms and contribute to closing these morality gaps.

Publication date: 14 May 2018Source: Cancer Cell, Volume 33, Issue 5Author(s): Junne Kamihara, Akiko ShimamuraIKZF1 plays an essential role in lymphopoiesis, and somatic IKZF1 variants in acute lymphoblastic leukemia (ALL) are associated with poor prognosis. In this issue of Cancer Cell, Churchman et al. add to the list of leukemia predisposition genes with the identification and characterization of germline IKZF1 variants in childhood ALL.

Source: Cancer CellCategory: Cancer & Oncology Source Type: research

Publication date: 14 May 2018Source: Cancer Cell, Volume 33, Issue 5Author(s): Michelle L. Churchman, Maoxiang Qian, Geertruy te Kronnie, Ranran Zhang, Wenjian Yang, Hui Zhang, Tobia Lana, Paige Tedrick, Rebekah Baskin, Katherine Verbist, Jennifer L. Peters, Meenakshi Devidas, Eric Larsen, Ian M. Moore, Zhaohui Gu, Chunxu Qu, Hiroki Yoshihara, Shaina N. Porter, Shondra M. Pruett-Miller, Gang WuSummarySomatic genetic alterations of IKZF1, which encodes the lymphoid transcription factor IKAROS, are common in high-risk B-progenitor acute lymphoblastic leukemia (ALL) and are associated with poor prognosis. Such alterations res…

Source: Cancer CellCategory: Cancer & Oncology Source Type: research

Induction chemotherapy results in high remission rate in high risk (HR) and very high risk (VHR) childhood acute lymphoblastic leukemia (ALL), but is associated with significant morbidity [1,2]. HR B-ALL is defined as: white blood cell count (WBC) ≥50,000/µL or age ≥10 years (National Cancer Institute (NCI) criteria) at presentation, or/and central nervous system (CNS) positive leukemia, or testicular leukemia [3–5]. Patients who are>13 years or experience induction failures; and/or if the leukemia blasts harbor mixed-lineage leukemia gene (MLL) rearrangements or intrachromosomal amplification of chrom…

Source: Leukemia ResearchCategory: Hematology Authors: Tags: Research paper Source Type: research

Publication date: October 2018 Source:Cancer Genetics, Volumes 226–227 Author(s): LB Baughn, MM Meredith, L Oseth, TA Smolarek, B Hirsch Acute lymphoblastic leukemia (ALL) represents the most common childhood malignancy. Although survival for pediatric B-ALL has approached 90%, variability in outcome among and within cytogenetically defined subgroups persists. While G-banding and fluorescence in situ hybridization (FISH) have been used to characterize leukemic clones, there is added value of chromosomal microarray and next generation sequencing in screening genome-wide for copy number aberrations, copy neutral loss …

Source: Cancer GeneticsCategory: Cancer & Oncology Source Type: research

Conclusions: We found that telomere attrition may be
related to the pathogenesis of childhood ALL, irrespective to TERT variants.
PMID: 29936725 [PubMed – in process]

Pediatric Blood&Cancer, EarlyView.

Source: Pediatric Blood and CancerCategory: Cancer & Oncology Authors:

International Journal of Cancer,Volume 0, Issue ja, -Not available-.

Source: International Journal of CancerCategory: Cancer & Oncology Authors:

Acute lymphoblastic leukemia (ALL) represents the most common childhood malignancy. Although survival for pediatric B-ALL has approached 90%, variability in outcome among and within cytogenetically-defined subgroups persists. While G-banding and fluorescence in situ hybridization (FISH) have been used to characterize leukemic clones, there is added value of chromosomal microarray and next generation sequencing in screening genome-wide for copy number aberrations, copy neutral loss of heterozygosity and nucleotide variations.

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research





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