T-ALL may be treatable by targeting signaling pathways affected by STIL-TAL1 fusion, according to a team from The Institute of Cancer Research, London, UK.

Source: CancerNetworkCategory: Cancer & Oncology Authors: Tags: Acute Lymphoblastic Leukemia News Source Type: news

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ConclusionDue to the frequent delay in HSV diagnosis and the safety of acyclovir, we recommend empirically administering acyclovir in patients suspected of HSV hepatitis.

Source: IDCasesCategory: Infectious Diseases Source Type: research

ConclusionThe frequency of most chromosomal rearrangements successfully identified in our study and their lineage correlated with those reported in the published data.

Publication date: October 2018Source: Cancer Genetics, Volumes 226–227Author(s): Nadine Berry, Rodney J. Scott, Rosemary Sutton, Toby N. Trahair, Philip Rowlings, Anoop K. Enjeti

Source: Cancer GeneticsCategory: Cancer & Oncology Source Type: research

Publication date: October 2018Source: Cancer Genetics, Volumes 226–227Author(s): Yassmine Akkari, Linda Baughn, Helene Bruyere, Tanner Hagelstrom, Rashmi Kanagal-Shamanna, Minjie Luo, Fady M. Mikhail, Beth Pitel, Gordana Raca, Mary Shago, Lina Shao, Lisa R. Smith, Teresa Smolarek, Ashwini Yenamandra, Betsy Hirsch

Source: Cancer GeneticsCategory: Cancer & Oncology Source Type: research

Publication date: Available online 5 April 2018Source: Acta Pharmaceutica Sinica BAuthor(s): Zijun Zhao, Yu Chen, Ngiambudulu M. Francisco, Yuanqing Zhang, Minhao WuAbstractChimeric antigen receptor T cell (CAR-T cell) therapy is a novel adoptive immunotherapy where T lymphocytes are engineered with synthetic receptors known as chimeric antigen receptors (CAR). The CAR-T cell is an effector T cell that recognizes and eliminates specific cancer cells, independent of major histocompatibility complex molecules. The whole procedure of CAR-T cell production is not well understood. The CAR-T cell has been used predominantly in t…

Publication date: 9 July 2018Source: Cancer Cell, Volume 34, Issue 1Author(s): Chelsea L. Dieck, Gannie Tzoneva, Farhad Forouhar, Zachary Carpenter, Alberto Ambesi-Impiombato, Marta Sánchez-Martín, Renate Kirschner-Schwabe, Scott Lew, Jayaraman Seetharaman, Liang Tong, Adolfo A. FerrandoSummaryActivating mutations in the cytosolic 5′-nucleotidase II gene NT5C2 drive resistance to 6-mercaptopurine in acute lymphoblastic leukemia. Here we demonstrate that constitutively active NT5C2 mutations K359Q and L375F reconfigure the catalytic center for substrate access and catalysis in the absence of allosteric a…

Source: Cancer CellCategory: Cancer & Oncology Source Type: research

Publication date: April 2018Source: Journal of Microbiology, Immunology and Infection, Volume 51, Issue 2Author(s): Gu-Lung Lin, Hsiu-Hao Chang, Chun-Yi Lu, Chung-Ming Chen, Meng-Yao Lu, Ping-Ing Lee, Shiann-Tarng Jou, Yung-Li Yang, Li-Min Huang, Luan-Yin ChangAbstractBackgroundInvasive fungal infection (IFI) causes significant morbidity and mortality in patients with hematological malignancies, especially those with acute myeloid leukemia (AML), recurrent acute leukemia, high-risk acute lymphoblastic leukemia, and after allogeneic hematopoietic stem cell transplantation. The study aimed to investigate the clinical charact…

This study was aimed to investigate clinical characteristics and treatment outcomes of pulmonary invasive fungal infection (IFI) among patients with hematological malignancy.MethodsAll patients with hematological malignancy who were treated at a medical centre from 2008 to 2013 were evaluated. Pulmonary IFI was classified according to the European Organization for Research and Treatment of Cancer 2008 consensus.ResultsDuring the study period, 236 (11.3%) of 2083 patients with hematological malignancy were diagnosed as pulmonary IFI, including 41 (17.4%) proven, 75 (31.8%) probable, and 120 (50.8%) possible cases. Among the…

Publication date: 9 July 2018Source: Cancer Cell, Volume 34, Issue 1Author(s): Chelsea L. Dieck, Gannie Tzoneva, Farhad Forouhar, Zachary Carpenter, Alberto Ambesi-Impiombato, Marta Sánchez-Martín, Renate Kirschner-Schwabe, Scott Lew, Jayaraman Seetharaman, Liang Tong, Adolfo A. FerrandoSummaryActivating mutations in the cytosolic 5′-nucleotidase II gene NT5C2 drive resistance to 6-mercaptopurine in acute lymphoblastic leukemia. Here we demonstrate that constitutively active NT5C2 mutations K359Q and L375F reconfigure the catalytic center for substrate access and catalysis in the absence of allosteric a…

Source: Cancer CellCategory: Cancer & Oncology Source Type: research

ConclusionDue to the frequent delay in HSV diagnosis and the safety of acyclovir, we recommend empirically administering acyclovir in patients suspected of HSV hepatitis.

Source: IDCasesCategory: Infectious Diseases Source Type: research





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