Charlotte Smith, from North Yorkshire, was diagnosed with acute lymphoblastic leukaemia when she was 11 weeks pregnant. Doctors warned carrying a child posed a danger to her life.

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ConclusionsDespite some limitations, our findings suggest that high coffee intake during pregnancy may increase risk of childhood ALL. Thus, current advice to limit caffeine intake during pregnancy to reduce risk of preterm birth may have additional benefits.

In this study, we found a moderate association between not having a low birthweight and an increased risk of acute leukemias. Birthweight ≥3500 g was also a risk factor for both types of leukemia. This suggests that a greater birthweight may increase the risk of acute leukemias in Mexican children.

Source: Cancer MedicineCategory: Cancer & Oncology Authors: Tags: Original Research Source Type: research

Authors: Höres T, Wendelin K, Schaefer-Eckart K
Spontaneous remission (SR) in acute lymphoblastic leukemia (ALL) is a rare phenomenon, but the disease course and its underlying processes are of basic and clinical interest. Herein is reported the case of a pregnant, 31-year-old patient who developed ALL, followed by septic shock and SR of ALL. Information is summarized from earlier case reports and incidences of SR in ALL, to identify common patterns. Furthermore, the phenomenon of SR is compared with another disease variant of ALL, termed prodromal or preceding-ALL (pre-ALL). SR and the aleukemic phas…

Source: Oncology LettersCategory: Cancer & Oncology Tags: Oncol Lett Source Type: research

ConclusionAlthough rising maternal age may account for some of the increase in childhood cancer incidence over time, other factors, not considered in this analysis, may also contribute to temporal trends.

Source: Pediatric Blood and CancerCategory: Cancer & Oncology Authors: Tags: RESEARCH ARTICLE Source Type: research

AbstractThe etiology of childhood cancers remains largely unknown, especially regarding environmental and behavioral risk factors. Unpacking the association between socioeconomic status (SES) and incidence may offer insight into such etiology. We tested associations between SES and childhood cancer incidence in a population-based case-cohort study (source cohort: Minnesota birth registry, 1989 –2014). Cases, ages 0–14 years, were linked from the Minnesota Cancer Surveillance System to birth records through probabilistic record linkage. Controls were 4:1 frequency matched on birth year (2,947 cases and 11,907 co…

This study identified potential relationships between maternal residential proximity to agricultural use of neurotoxic pesticides and poorer neurodevelopment in children.

Received: 08 January 2016
Revised: 13 May 2016
Accepted: 14 June 2016
Published: 25 May 2017
Address correspondence to R. Gunier, Center for Environmental Research and Childrens Health (CERCH), School of Public Health, University of California at Berkeley, 1995 University Ave., Suite 265, Berkeley, CA 94704. Telephone: (510) 847-3858. E-mail: [email protected]
A.B. is a volunteer member of the Board for…

Source: EHP ResearchCategory: Environmental Health Authors: Tags: Research Source Type: research

Tobacco smoke exposure has been associated with risk of childhood acute lymphoblastic leukemia (ALL). Understanding the relationship between tobacco exposures and specific mutations may yield etiologic insights. We carried out a case-only analysis to explore whether prenatal and early-life tobacco smoke exposure influences the formation of leukemogenic genomic deletions. Somatic copy number of 8 genes frequently deleted in ALL (CDKN2A, ETV6, IKZF1, PAX5, RB1, BTG1, PAR1 region, and EBF1) was assessed in 559 pretreatment tumor samples from the California Childhood Leukemia Study. Parent and child’s passive tobacco exposure …

Source: Cancer ResearchCategory: Cancer & Oncology Authors: Tags: Prevention and Epidemiology Source Type: research

CONCLUSIONS: The risk of ALL was elevated in young children with paternal occupational pesticide exposure during the perinatal period, using more detailed occupational information for exposure classification.
PMID: 28319818 [PubMed – as supplied by publisher]

Source: Environmental ResearchCategory: Environmental Health Authors: Tags: Environ Res Source Type: research

Long‐term follow‐up of 11 children with 6‐thioguanine‐induced hepatoportal toxicity is described. Features of persistent portal hypertension in eight patients after 9.7 ± 3.4 years (mean ± SD) of treatment were more common in late presenters. Splenomegaly, thrombocytopenia and altered hepatic echotexture were seen in six, eight and seven patients, respectively. One of the thrombocytopenic patients had heavy menstrual bleeding and pregnancy loss. Five of six patients who underwent upper gastrointestinal endoscopy had esophageal varices and four underwent banding. Late presentation in a subset …

Source: Pediatric Blood and CancerCategory: Cancer & Oncology Authors: Tags: Brief Report Source Type: research

Conclusions Maternal consumption of specific food groups comprising“healthy” items of the Mediterranean diet, preconception use of folic acid and intake of vitamins during pregnancy were associated with decreased ALL risk. Further research is needed, however preferably with homogeneous dietary information and data on immunophenotypic/cytogenetic subtypes to also explore the interaction of specific macro- and micronutrients intake with gene polymorphisms.

Source: Cancer EpidemiologyCategory: Cancer & Oncology Source Type: research

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