Cancer cell cycle inhibitor is Lin BioScience’s second candidate to receive Orphan Drug Designation

SAN DIEGO, April 24, 2018 — (Healthcare Sales &Marketing Network) — Lin BioScience, a drug development company targeting unmet clinical needs in onco… Biopharmaceuticals, Oncology, FDA Lin BioScience, LBS-007, acute lymphoblastic leukemia

Source: HSMN NewsFeedCategory: Pharmaceuticals Source Type: news

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B-ALL is the most common pediatric malignancy, accounting for ∼25% of cancers before 15 years of age. It represents a heterogeneous disease with morphologically identical leukemic cells seemingly arising from different biological mechanisms. Initial workup and evaluation of B-ALL has become increasingly complex partly due to the genetic abnormalities that ar e targets for specific therapy and play an important role in monitoring residual disease. Clinical management and risk stratification depend largely on the results of chromosomal abnormalities obtained using conventional cytogenetics and FISH testing, and a testing…

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

Chromosome analysis and FISH demonstrate that ploidy changes, particularly gains in ploidy, are common in many tumors. However, with DNA copy number microarray or sequencing, all ploidy information is relative rather than exact. In this context, accurate ploidy assessment is based on software algorithms and the user’s experience in analysis of the data; FISH or karyotype information can serve in a supportive role for challenging cases. In rare cases of near-haploid genomes, it is more common for the predominant clone to be the doubling of the haploid line, as is the case for near-haploid acute lymphoblastic leukemia.

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

T-cell acute lymphoblastic leukemia (T-ALL) represents a rare hematologic malignancy with poor outcomes in both children and adults. This leukemia typically features a primary abnormality that provides maturation arrest, in addition to secondary abnormalities associated with proliferation and cell survival. The wide-ranging scale of these genomic abnormalities requires multiple technical approaches, from classical karyotyping to chromosomal microarray and molecular sequencing, which confounds and may preclude complete characterization of T-ALLs.

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

Background: Whole genome high density (HD) SNP microarray analysis provides valuable insights into the cancer genome, unveiling important prognostic findings and therapeutic targets.

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. Genomic alterations in B-ALL are essential for disease diagnosis, prognosis, and treatment. We performed integrated genomic analysis on 136 pediatric B-ALL patients using the CHOP Comprehensive Hematological Cancer NGS Panel along with conventional cytogenetic studies. The panel interrogates 118 cancer genes for sequence and copy number variants (CNV) and 110 genes for known and novel fusions. Clinically significant genomic changes were identified in 89.7% of patients.

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

Contributors : Stefan Feske ; Shella S FleurSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusT-cell acute lymphoblastic leukemia (T-ALL) is a malignancy of T cell progenitors that in most patients is associated with activating mutations in the NOTCH1 pathway. Recent reports have indicated a link between Ca2+ homeostasis in the endoplasmic reticulum (ER), the regulation of NOTCH1 signaling and T-ALL. Here we investigated the role of store-operated Ca2+ entry (SOCE) in T-ALL. SOCE is a Ca2+ influx pathway that is mediated by the plasma membrane Ca2+ channel ORAI1 and its activators STIM1…

Source: GEO: Gene Expression OmnibusCategory: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

ConclusionDue to the frequent delay in HSV diagnosis and the safety of acyclovir, we recommend empirically administering acyclovir in patients suspected of HSV hepatitis.

Source: IDCasesCategory: Infectious Diseases Source Type: research

ConclusionThe frequency of most chromosomal rearrangements successfully identified in our study and their lineage correlated with those reported in the published data.

Publication date: October 2018Source: Cancer Genetics, Volumes 226–227Author(s): Nadine Berry, Rodney J. Scott, Rosemary Sutton, Toby N. Trahair, Philip Rowlings, Anoop K. Enjeti

Source: Cancer GeneticsCategory: Cancer & Oncology Source Type: research

Publication date: October 2018Source: Cancer Genetics, Volumes 226–227Author(s): Yassmine Akkari, Linda Baughn, Helene Bruyere, Tanner Hagelstrom, Rashmi Kanagal-Shamanna, Minjie Luo, Fady M. Mikhail, Beth Pitel, Gordana Raca, Mary Shago, Lina Shao, Lisa R. Smith, Teresa Smolarek, Ashwini Yenamandra, Betsy Hirsch

Source: Cancer GeneticsCategory: Cancer & Oncology Source Type: research





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