An Italian diagnostic imaging company is teaming with a Chicago startup to study whether microbubbles can deliver personalized gene therapy to treat high LDL cholesterol.
Microbubble technology, combined with contrast-enhanced ultrasound, has been used diagnostically for years and more recently has inspired research for treatment of disease. Milan-based Bracco Imaging, S.p.A. is working with Steven Feinstein, a professor of medicine at Rush University Medical Center and president of SonoGene, LLC to pursue the treatment possibilities further. A CEUS researcher, Feinstein is also co-president of the  International Contrast Ultrasound Society.
“The experience Bracco has developed during the past decade allows us to understand and control the production of microbubbles as well as the interaction with the ultrasound beam in a way which enables Bracco to design dedicated microbubbles also for therapeutic use,” Roberto Cattaneo, a spokesperson for Bracco, told MD+DI in an email.  “Many years of pre-clinical research in the Bracco lab as well as in academic labs have identified clinical scenarios where the therapeutic use of microbubbles seems technically feasible and provides a significant clinical value.”
Microbubble manufacturer Bracco has been working for the past decade to understand and control the bubbles’ interaction with the ultrasound beam so that they can be deployed for therapeutic use. Bracco chose to work with SonoGene becau…

Source: MDDICategory: Medical Devices Authors: Tags: R & D Source Type: news

Related Links:

Publication date: 5 September 2018Source: International Journal of Pharmaceutics, Volume 548, Issue 1Author(s): Wessam Hamdy Abd-Elsalam, Sara Nageeb El-Helaly, Mohammed Abdallah Ahmed, Abdulaziz Mohsen Al-mahallawiAbstractThe study aimed to fabricate innovative drug-phospholipid complexes termed “sonocomplexes” adopting ultrasound irradiation to increase the liposolubility and to enhance the intestinal absorption of rosuvastatin as a model drug for BCS class III active pharmaceutical ingredients (APIs). A 22 full factorial design was fashioned to investigate the influence of phosphatidylcholine content in the …

Publication date: 5 September 2018Source: International Journal of Pharmaceutics, Volume 548, Issue 1Author(s): Ayat A. Allam, Sarah J. Potter, Sergey L. Bud’ko, Donglu Shi, Dina F. Mohamed, Fawzia S. Habib, Giovanni M. PaulettiAbstractPoor aqueous solubility, chemical instability, and indiscriminate cytotoxicity have limited clinical development of camptothecin (CPT) as potent anticancer therapeutic. This research aimed at fabricating thermoresponsive nanocomposites that enhance solubility and stability of CPT in aqueous milieu and enable stimulus-induced drug release using magnetic hyperthermia. 1,2-Dipalmitoyl-sn-glycer…

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Tao-Li Wang, Chen-Sheng Ouyang, Li-Zhu LinAbstractLung cancer is the leading cause of cancer death worldwide. Chemotherapy is one of the most effective strategies for lung cancer treatment. However, the side effects of chemotherapy limit the application of chemotherapeutic agents. The β-Asarone, a low-toxicity natural compound from a traditional Chinese medicinal herb, has been demonstrated to display anticancer activities in multiple cancer types. However, the anticancer activities of β-Asarone in lung cancer have not be…

In this study, we investigated the molecular mechanisms of the anti-leukemia effects of C10 on different leukemia cells in vitro. C10 showed strong inhibition of proliferation of the human erythroleukemia cell line HEL and human myeloid leukemia cell line K562, and several cell and flow cytometer assays showed that inhibition by C10 was due to the regulation of gene expression or phosphorylation in the apoptosis and autophagy pathways. The results showed that C10 regulated the expression of Bax, c-Myc, Bcl-2, P38/AMPK and ERK 1/2, activated the expression of Caspase-3, -8, and PARP at the protein level in the apoptosis pat…

In conclusion, naringenin was found to have direct or indirect blocking activity on voltage-gated sodium channels encoded by the SCN9A gene.Graphical abstract

ConclusionIn summary, our study is the first to show that upregulation of miR-185 enhances the sensitivity of CRC cells to ionizing radiation. miR-185 may act as a novel biomarker of radioresistance and may clinically enhance the radiation response of CRC.

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Hongyan Zhang, Yuan Wang, Jibin Lu, Yanyan ZhaoAbstractRecent evidence indicates that long noncoding RNAs (lncRNAs) play a critical role in the regulating cellular processes such as differentiation, proliferation, metastasis and apoptosis. These lncRNAs are found to be dysregulated in a variety of cancers. However, the underlying mechanisms of lncRNAs action in lung adenocarcinoma remain unclear. We investigated expression of the lncRNA LINC00222 in 76 lung adenocarcinoma tissues and paired normal lung tissues and found that LINC00…

ConclusionMALAT1 knockdown attenuated myocardial apoptosis through suppressing Pten expression by sponging miR-320 in mouse AMI.Graphical abstractMALAT1 may serve as a sponge for miR-320 to upregulate Pten, a direct target of miR-320 in a mouse model of acute myocardial infarction.

ConclusionA high concentration of TGJ can improve glucose and lipid metabolism by activating the IRS/PI3K/AKT signaling pathway.

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Fatemeh Hashemi- Niasari, Azra Rabbani-Chadegani, Mahdieh Razmi, Soudabeh FallahAbstractBerberine, is a plant alkaloid, proved to have anticancer effect on various cancers. Theophylline (TH), a natural product, is widely used in the treatment of respiratory difficulties. The present study designed to elucidate the effects of theophylline and berberine combination on breast cancer cells cytotoxicity, gene expression and cell cycle. MTT assay revealed that berberine inhibited MDA-MB-231 breast cancer cells viability in a time and dos…





Source link

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Enter Captcha Here : *

Reload Image