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Publication date: 5 September 2018Source: International Journal of Pharmaceutics, Volume 548, Issue 1Author(s): Ayat A. Allam, Sarah J. Potter, Sergey L. Bud’ko, Donglu Shi, Dina F. Mohamed, Fawzia S. Habib, Giovanni M. PaulettiAbstractPoor aqueous solubility, chemical instability, and indiscriminate cytotoxicity have limited clinical development of camptothecin (CPT) as potent anticancer therapeutic. This research aimed at fabricating thermoresponsive nanocomposites that enhance solubility and stability of CPT in aqueous milieu and enable stimulus-induced drug release using magnetic hyperthermia. 1,2-Dipalmitoyl-sn-glycer…

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Tao-Li Wang, Chen-Sheng Ouyang, Li-Zhu LinAbstractLung cancer is the leading cause of cancer death worldwide. Chemotherapy is one of the most effective strategies for lung cancer treatment. However, the side effects of chemotherapy limit the application of chemotherapeutic agents. The β-Asarone, a low-toxicity natural compound from a traditional Chinese medicinal herb, has been demonstrated to display anticancer activities in multiple cancer types. However, the anticancer activities of β-Asarone in lung cancer have not be…

In conclusion, naringenin was found to have direct or indirect blocking activity on voltage-gated sodium channels encoded by the SCN9A gene.Graphical abstract

ConclusionIn summary, our study is the first to show that upregulation of miR-185 enhances the sensitivity of CRC cells to ionizing radiation. miR-185 may act as a novel biomarker of radioresistance and may clinically enhance the radiation response of CRC.

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Hongyan Zhang, Yuan Wang, Jibin Lu, Yanyan ZhaoAbstractRecent evidence indicates that long noncoding RNAs (lncRNAs) play a critical role in the regulating cellular processes such as differentiation, proliferation, metastasis and apoptosis. These lncRNAs are found to be dysregulated in a variety of cancers. However, the underlying mechanisms of lncRNAs action in lung adenocarcinoma remain unclear. We investigated expression of the lncRNA LINC00222 in 76 lung adenocarcinoma tissues and paired normal lung tissues and found that LINC00…

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Evangeline Breeta R., Perinba Danisha Jesubatham, Berlin Grace V.M., Viswanathan S., Srividya S.AbstractLung cancer is a malignant tumour with minimal survival rate and the current treatments are not showing complete remission of tumour and have many side effects. Thus a natural herbal medicine with good anti-cancer properties is highly demanded. Thuja orientalis L. is a traditionally used medicine to cure cough, bronchitis, excessive menstruation, asthma, skin infection and premature baldness. In addition, recent studies have reve…

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Fatemeh Hashemi- Niasari, Azra Rabbani-Chadegani, Mahdieh Razmi, Soudabeh FallahAbstractBerberine, is a plant alkaloid, proved to have anticancer effect on various cancers. Theophylline (TH), a natural product, is widely used in the treatment of respiratory difficulties. The present study designed to elucidate the effects of theophylline and berberine combination on breast cancer cells cytotoxicity, gene expression and cell cycle. MTT assay revealed that berberine inhibited MDA-MB-231 breast cancer cells viability in a time and dos…

Publication date: October 2018Source: Biomedicine &Pharmacotherapy, Volume 106Author(s): Binghua Zhou, Lijun Li, Yajing Li, Huimin Sun, Changchun ZengAbstractThe long non-coding RNA small nucleolar RNA host gene 12 (SNHG12) overexpression was found in various tumors and the dysregulated expression of SNHG12 contributed to multidrug resistance in non-small cell lung cancer. However, the role of SNHG12 in doxorubicin resistance of osteosarcoma is still unclear. In present study, we explored the function and underlying mechanism of SNHG12 on doxorubicin resistance in osteosarcoma. High expression of SNHG12 was associated …

Conclusion The patient-based sensitivity, specificity and accuracy of WB MRI including DWI were comparable with those of PET/MRI. On the other hand, the lesion-based sensitivities of WB MRI were relatively low, mainly because of the low detectability of small lymph node metastasis. The combination of T2WI and DWI showed acceptable detectability; however, the T1WI sequence showed no additional value to detect malignant lesions on both lesion- and patient-based sensitivities.

Source: Journal of Nuclear MedicineCategory: Nuclear Medicine Authors: Tags: Other Solid Tumors Posters Source Type: research

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