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Publication date: Available online 10 July 2018Source: Biochimica et Biophysica Acta (BBA) – Molecular Cell ResearchAuthor(s): Indu AmbudkarAbstractSalivary glands secrete saliva, a mixture of proteins and fluids, which plays an extremely important role in the maintenance of oral health. Loss of salivary secretion causes a dry mouth condition, xerostomia, which has numerous deleterious consequences including opportunistic infections within the oral cavity, difficulties in eating and swallowing food, and problems with speech. Saliva secretion is regulated by stimulation of specific signaling mechanisms within the acinar cel…

Doctors in California are trying to solve a family’s stunning medical mystery. Two young siblings, four and six years old, were diagnosed with the same kind of brain tumor within two weeks of each other. Now, their parents are speaking out in hopes of raising awareness and encouraging new research. Jamie Yuccas reports.

Publication date: Available online 10 July 2018Source: Saudi Journal of Biological SciencesAuthor(s): Nida Idrees, B. Tabassum, ElsayedFathi Abd_Allah, Abeer Hashem, Robeena Sarah, Mohammad HashimAbstractWater is considered a vital resource because it is necessary for all aspects of human and ecosystem survival. However, due to natural processes and anthropogenic activities, various pollutants have been added to the ground water system. Among these, heavy metals are some of the most serious pollutants. Cd, a toxic heavy metal used in Ni-Cd batteries, the colouration of plastic and various discarded electronic products rele…

This study was designed to investigate the role and the underlying mechanism of GRIM-19 in osteosarcoma progression.Materials and methodsOsteosarcoma tissues and cell lines were utilized to analyze the expressions of GRIM-19 in osteosarcoma by qRT-PCR and Western blot. Methods containing flow cytometry, irradiation exposure, cells inoculation, plasmid transfection, and protein immunoprecipitation were used to investigate the underlying mechanisms of GRIM-19 in osteosarcoma progression.Key findingsGRIM-19 is downregulated in osteosarcoma tissues and cell lines. Exposure to radiation induces osteosarcoma cell apoptosis by up…

Source: Life SciencesCategory: Biology Source Type: research

Publication date: Available online 11 July 2018Source: Journal of Thermal BiologyAuthor(s): Ming Ma, Yu Zhang, Ning GuAbstractThe treatment of cancer by hyperthermia requires prediction, monitoring and control of the temperature within the tumor. Infrared thermography (IRT) was presented in this paper as a noninvasive temperature monitoring method used in magnetic nanoparticle hyperthermia (MNH). We tried to use this surface temperature measurement method to get information about the intratumoral temperature. Experimental in vitro MNH studies were performed on gel tumor-tissue phantoms which were constructed to simulate th…

Publication date: Available online 11 July 2018Source: Journal of Thermal BiologyAuthor(s): S.M. Chapal Hossain, Xin Zhang, Zeeshan Haider, Peng Hu, Gang ZhaoAbstractCryosurgery is a promising novel minimally invasive surgical technique to eradicate carcinoma and non-carcinoma tissues by freezing. In this research, we applied a transient 3D two-phase refrigerant flow model inside the LN2 boiling chamber as well as a bioheat transfer model inside the tissues to evaluate the optimized ablation outcome during prostatic cryosurgery. For the evaluation of the scenarios, a defect function was used that considers non-ablated targ…

Publication date: Available online 11 July 2018Source: Chemico-Biological InteractionsAuthor(s): He-He Hu, Dan-Qian Chen, Yan-Ni Wang, Ya-Long Feng, Gang Cao, Nosratola D. Vaziri, Ying-Yong ZhaoAbstractTransforming growth factor-β1 (TGF-β1) is considered as a crucial mediator in tissue fibrosis and causes tissue scarring largely by activating its downstream small mother against decapentaplegic (Smad) signaling. Different TGF-β signalings play different roles in fibrogenesis. TGF-β1 directly activates Smad signaling which triggers pro-fibrotic gene overexpression. Excessive studies have demonstrated that…

Publication date: Available online 11 July 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Azam Sargazi, Fereshteh Shiri, Sheida Keikha, Mostafa Heidari MajdAbstractHyaluronic acid (HA) is increasingly investigated for biomedical applications such as regenerative medicine, aesthetic medicine, and drug delivery. Accordingly, conjugation of HA to PEGylated MNPs could increase the active targeting ability of nano-drug carriers toward CD44 receptors and be useful in a clinical setting such as drug delivery. So, we chemically conjugated mitoxantrone (MTX) to HA-PEGylated MNPs to use concurrent advantages such as pr…

Publication date: Available online 10 July 2018Source: Colloids and Surfaces B: BiointerfacesAuthor(s): Pham Thi Thu Phuong, Sungin Lee, Changkyu Lee, Bohyung Seo, Sanghyun Park, Kyung Taek Oh, Eun Seong Lee, Han-Gon Choi, Beom Soo Shin, Yu Seok YounAbstractChlorin e6 (Ce6) has attracted considerable interest as a promising second-generation photosensitizer for photodynamic therapy (PDT). However, the in vivo availability of Ce6 is significantly restricted by its low water solubility and poor ability to target tumors. We sought to overcome the limitations of Ce6 by using albumin nanoparticles with nabTM (nanoparticle album…

Publication date: August 2018Source: Biochimica et Biophysica Acta (BBA) – Proteins and Proteomics, Volume 1866, Issue 8Author(s): Xin-Yu Zhang, Hui Guo, Bing Han, Xu-Min Zhang, Ying Huang, Yang Yang, Ying Liu, Xiao-Xi Guo, Qian Hao, Su An, Tian-Rui XuAbstractA-Raf is a member of the Raf kinase family. Unlike B-Raf and C-Raf, the functions of A-Raf remain obscure. To gain more insight into the biological functions of A-Raf, we investigated the A-Raf interactome using proteomics. We found 132 proteins that interact with A-Raf and confirmed the interaction of 12 of these proteins with A-Raf by western blotting. Our data sugg…





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