A new CAR T cell has shown efficacy in adults with acute lymphoblastic leukemia (ALL), as the first of these products is hailed as a’game changer’in pediatric ALL.Medscape Medical News

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AbstractPurpose of ReviewOutcomes for older adults with acute lymphoblastic leukemia (ALL) remain poor, and allogeneic hematopoietic stem cell transplant (HSCT) remains a potentially curative modality. However, benefits are offset by high rates of non-relapse mortality (NRM) in patients undergoing myeloablative conditioning (MAC) regimens. Reduced intensity conditioning (RIC) regimens can extend this therapy to adults who are unfit for MAC, although at the cost of higher relapse rates. In this review, we discuss evidence to support the usage of RIC regimens, controversies, and potential strategies to improve transplant out…

Toma Keser
Branka Zorc

Novel primaquine (PQ) and halogenaniline asymmetric fumardiamides 4a–f, potential Michael acceptors, and their reduced analogues succindiamides 5a–f were prepared by simple three-step reactions: coupling reaction between PQ and mono-ethyl fumarate (1a) or mono-methyl succinate (1b), hydrolysis of PQ-dicarboxylic acid mono-ester conjugates 2a,b to corresponding acids 3a,b, and a coupling reaction with halogenanilines. 1-[bis(Dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU) was used as a coupling reagent along with Hüni…

Source: MoleculesCategory: Chemistry Authors: Tags: Article Source Type: research

Conditions:   Childhood Acute Lymphoblastic Leukemia in Remission;   Childhood Brain Tumor;   Physical Activity;   Physical Disability Intervention:   Sponsor:   Federal Research Institute of Pediatric Hematology, Oncology and Immunology Recruiting

AbstractImmunotherapy has played an important part in improving the life of patients with lymphoproliferative diseases especially since the addition of rituximab to chemotherapy in the CD20-positive neoplasms in the 1990s. While this field of passive immunotherapy is continuously evolving, several breakthroughs will expand the treatment modalities to include more active immunotherapy. With the approval of immune checkpoint-blocking antibodies for Hodgkin lymphoma and bispecific antibodies for acute lymphoblastic leukemia (ALL), activation of endogenous T cells already plays a role in several lymphoid malignancies. With the…

In this study, the inhibitory effect of Brucea javanica (BJ) on cell growth and inflammation was confirmed in human T-cell acute lymphocytic leukemia (T-ALL) cells, and its efficacy as an antileukemic agent was verified. Our results showed that BJ extract induced caspase-dependent apoptosis of T-ALL Jurkat cells through inhibition of the CK2-mediated signaling pathway, while exerting no significant cytotoxicity in normal peripheral blood mononuclear cells. Moreover, BJ extract suppressed the NF-κB signaling pathway, thus, inhibiting the interleukin (IL)-2 expression induced by phorbol 12-myristate 13-acetate (PMA) an…

This study provides essential corroboratory evidence for CEP72 rs924607 and highlights the importance of drug transporter and inherited neuropathy genes in VIPN. This article is protected by copyright. All rights reserved.
PMID: 29999516 [PubMed – as supplied by publisher]

Source: Clinical Pharmacology and TherapeuticsCategory: Drugs & Pharmacology Authors: Tags: Clin Pharmacol Ther Source Type: research

Authors: Trussardi Fayh AP, de Carvalho Gomes C, Schroeder HT, Henrique de Lemos Muller C, Maria de Araújo Moura Lemos T, Krause M
Background: Acute lymphoblastic leukemia (ALL) is associated with higher levels of pro-inflammatory cytokines and oxidative stress. Recently, the levels of extracellular heat shock protein 72 (eHSP72) were found to be elevated in ALL, and its elevation associated with poor prognosis. Therefore, considering the possible role of eHSP72 as a modulator of the immunological system and metabolism, the aim of this study was to describe the response of eHSP72 to the induction ph…

Source: OncotargetCategory: Cancer & Oncology Tags: Oncotarget Source Type: research

B-ALL is the most common pediatric malignancy, accounting for ∼25% of cancers before 15 years of age. It represents a heterogeneous disease with morphologically identical leukemic cells seemingly arising from different biological mechanisms. Initial workup and evaluation of B-ALL has become increasingly complex partly due to the genetic abnormalities that ar e targets for specific therapy and play an important role in monitoring residual disease. Clinical management and risk stratification depend largely on the results of chromosomal abnormalities obtained using conventional cytogenetics and FISH testing, and a testing…

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

Chromosome analysis and FISH demonstrate that ploidy changes, particularly gains in ploidy, are common in many tumors. However, with DNA copy number microarray or sequencing, all ploidy information is relative rather than exact. In this context, accurate ploidy assessment is based on software algorithms and the user’s experience in analysis of the data; FISH or karyotype information can serve in a supportive role for challenging cases. In rare cases of near-haploid genomes, it is more common for the predominant clone to be the doubling of the haploid line, as is the case for near-haploid acute lymphoblastic leukemia.

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

T-cell acute lymphoblastic leukemia (T-ALL) represents a rare hematologic malignancy with poor outcomes in both children and adults. This leukemia typically features a primary abnormality that provides maturation arrest, in addition to secondary abnormalities associated with proliferation and cell survival. The wide-ranging scale of these genomic abnormalities requires multiple technical approaches, from classical karyotyping to chromosomal microarray and molecular sequencing, which confounds and may preclude complete characterization of T-ALLs.

Source: Cancer Genetics and CytogeneticsCategory: Genetics & Stem Cells Authors: Source Type: research

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