Cystic fibrosis is among factors which may influence the complex relationship of genetics to Barrett’s esophagus and adenocarcinoma, according to a large-scale meta-analysis.Reuters Health Information

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CONCLUSION: In this population based study, there was no increased risk of SPCA among GEP-NEN patients. The clinical work-up in newly diagnosed GEP-NEN patients likely explains the positive short-term association followed by a negative association.

CONCLUSION: Goblet cell carcinomas is a distinct entity which should be delineated from the classical appendiceal carcinoids. Its clinical evolution obliges a more aggressive therapeutic strategy.
PMID: 30081726 [PubMed – as supplied by publisher]

(University of Colorado Anschutz Medical Campus) University of Colorado Cancer Center and M.D. Anderson Cancer Center study shows KRAS-driven lung cancers are also marked by high levels of ‘gel-forming mucins,’ as seen in some forms of asthma, chronic obstructive pulmonary disease and cystic fibrosis. The study, published Aug. 9 in the journal JCI Insight, also pinpoints a cause of increased mucin production, namely the gene MUC5AC.

The overall prognosis of patients with esophageal cancer has improved in recent decades due to surgical and medical progress, but overall survival remains poor. Better patient selection and tailored treatment are needed. Different prognostic factors linked with the patient, tumoral characteristics and treatment with curative intent have been identified and are the purpose of this review. Tumor detection at an earlier stage, the advent of new molecules and therapeutic combinations, and the centralization of management in high-volume centers should help to improve the prognosis of esophageal cancer.

Source: Digestive and Liver DiseaseCategory: Gastroenterology Authors: Tags: Review Article Source Type: research

Although radical gastrectomy with D2 lymph node dissection has become the standard surgical approach for locally advanced gastric cancer, patients still have a poor prognosis after operation. Previously, we pr…

Source: TrialsCategory: General Medicine Authors: Tags: Study protocol Source Type: research

ConclusionsExclusion of CF is imperative for patients with bronchiectasis and CFTR testing should be implemented in usual screening for investigating bronchiectasis etiology. Physicians taking care of bronchiectasis patients should be aware of CFTR testing and its limitations in the adult population. Further studies on CFTR expression in human lung and translational research might elucidate the possible role of CFTR in the pathogenesis of bronchiectasis.

DiscussionPrevious studies have demonstrated the safety and feasibility of D2  + CME for locally advanced gastric cancer; however, there is still a lack of evidence to support its therapeutic effect. Thus, we performed this randomized trial to investigate whether D2 + CME can improve oncologic outcomes of patients with locally advanced gastric cancer. The findings fro m this trial may potentially optimize the surgical procedure and may improve the prognosis of patients with locally advanced gastric cancer.Trial,NCT01978444. Registered on October 31, 2013.

Source: TrialsCategory: Research Source Type: clinical trials

ConclusionsRadiologic measurements could not precisely predict tumor invasion and prognosis. Making treatment strategies solely according to TS-CT findings for GGO tumor is inappropriate.

Publication date: 15 January 2019Source: Food Chemistry, Volume 271Author(s): Can Altınelataman, Olga Koroleva, Tatyana Fedorova, Anna Torkova, Ksenia Lisitskaya, Mikhail Tsentalovich, Aleksey Kononikhin, Igor Popov, Daria Vasina, Leonid Kovalyov, Ufuk ÇelikAbstractEuropean seabass (Dicentrarchus labrax, Linnaeus, 1758) (L) and gilthead seabream (Sparus aurata, Linnaeus, 1758) (C) muscles were hydrolysated by Alcalase (Lalc, Calc) and Chymotrypsin (Lch, Cch) then hydrolysates were examined and their peptide profiles obtained. A total of 765, 794, 132 and 232 peptides were identified in Calc, Lalc, Cch and Lch, resp…

Source: Food ChemistryCategory: Food Science Source Type: research

ConclusionsCompounds 1–5 are valuable cytotoxic compounds that could be used to combat MDR cancer cells. Benzophenoe 5 is the most active molecule and deserve more investigations to develop new anticancer drugs.Graphical abstractBetulin (1), mundulea lactone (2), seputhecarpan A (3), seputheisoflavone (4) and epunctanone (5) had cytotoxic effects on a panel of 9 cancer cell lines with IC50 values below 70 µM. Compound 5 had the best activity and induced apoptosis in CCRF-CEM leukemia cells through alteration of MMP and increase in ROS production. Compound 5 also induced ferroptotic cell death.

Source: PhytomedicineCategory: Drugs & Pharmacology Source Type: research

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