Margaret Daffodil Graham tries to live a healthy life, particularly since she has a health issue that requires constant attention. Like more than 100 million other Americans, the 74-year-old from Winston-Salem, N.C., has high blood pressure, and she has been taking medication to control it since she was in her 30s. So when she read that her nearby hospital, Wake Forest Baptist Medical Center, was looking for people with hypertension to volunteer for a study, she quickly signed up, knowing the doctors would monitor her blood pressure more intensively and hopefully lower her risk of developing heart disease and stroke.

What Graham didn’t realize was that by joining the trial, she wouldn’t just be benefiting her heart. The study, called SPRINT MIND, was designed to test whether aggressively lowering blood pressure would have an effect on people’s risk of cognitive decline, including symptoms of dementia related to Alzheimer’s disease.

Indeed, the trial’s results are now the first solid confirmation that lowering blood pressure reduces the risk of both mild cognitive impairment (MCI), a degree of brain decline that’s considered the gateway to dementia, and probable dementia. It was a revelation to Graham as well as others who volunteered. “It never occurred to me that controlling my blood pressure could protect me from dementia,” says Arthur Lane, 89, another participant in the study. “I think this is wonderful.”
Some …

Source: TIME: HealthCategory: Consumer Health News Authors: Tags: Uncategorized Aging Alzheimer’s Research Source Type: news

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After an eight-week trial, and three days deliberating, the jury found Monsanto’s product did cause Johnson’s cancer, and the company ‘acted with malice and fraud and should be punished’.

A California jury on Friday found Monsanto liable in a lawsuit filed by a man who alleged the company’s glyphosate-based weed-killers, including Roundup, caused his cancer and ordered the company to pay $289 million in damages.

Source: Reuters: HealthCategory: Consumer Health News Tags: healthNews Source Type: news

Authors: Furusawa Y, Yamada S, Itai S, Nakamura T, Fukui M, Harada H, Kaneko MK, Kato Y
Abstract
Rat podoplanin (rPDPN) is a recognized lymphatic endothelial cell marker and is expressed on the podocytes of kidney and type I lung alveolar cells. rPDPN is a type I transmembrane sialoglycoprotein and induces platelet aggregation via the C-type lectin-like receptor-2 of platelets. It comprises four platelet aggregation-stimulating (PLAG) domains: PLAG1-3, present in the N-terminus, and PLAG4, in the center of the PDPN protein. Previously, we developed a mouse anti-rPDPN monoclonal antibody clone, PMab-2, by immunizing…

Publication date: Available online 10 August 2018Source: Biochimica et Biophysica Acta (BBA) – Molecular Basis of DiseaseAuthor(s): Hui Emma Zhang, James M. Henderson, Mark D. GorrellAbstractHepatocellular carcinoma (HCC) represents ~90% of all cases of primary liver cancer and occurs predominantly in patients with underlying chronic liver disease and cirrhosis. Establishing appropriate animal models for HCC is required for basic and translational studies, especially the models that can recapitulate one of the human disease settings. Current animal models can be categorized as chemically-induced, genetically-engineered, xe…

CONCLUSIONS Both Gail model and Tyrer-Cuzick models can be used to evaluate breast cancer risk. The Gail model has relatively lower accuracy in evaluating breast cancer risk in Jiangxi province of China and the Tyrer-Cuzick model had relatively higher accuracy.
PMID: 30089770 [PubMed – in process]

Authors: Zhu L, Gangadaran P, Kalimuthu S, Oh JM, Baek SH, Jeong SY, Lee SW, Lee J, Ahn BC
Abstract
Exosomes are endogenous nanocarriers that can deliver biological information between cells. They are secreted by all cell types, including immune cells such as natural killer (NK) cells. However, mammalian cells release low quantities of exosomes, and the purification of exosomes is difficult. Here, nanovesicles were developed by extrusion of NK cells through filters with progressively smaller pore sizes to obtain exosome mimetics (NK-EM). The anti-tumour effect of the NK-EM was confirmed in vitro and in vivo. The mo…

Margaret Daffodil Graham tries to live a healthy life, particularly since she has a health issue that requires constant attention. Like more than 100 million other Americans, the 74-year-old from Winston-Salem, N.C., has high blood pressure, and she has been taking medication to control it since she was in her 30s. So when she read that her nearby hospital, Wake Forest Baptist Medical Center, was looking for people with hypertension to volunteer for a study, she quickly signed up, knowing the doctors would monitor her blood pressure more intensively and hopefully lower her risk of developing heart disease and stroke.

What…

Source: TIME: HealthCategory: Consumer Health News Authors: Tags: Uncategorized Aging Alzheimer’s Research Source Type: news

Margaret Daffodil Graham tries to live a healthy life, particularly since she has a health issue that requires constant attention. Like more than 100 million other Americans, the 74-year-old from Winston-Salem, N.C., has high blood pressure, and she has been taking medication to control it since she was in her 30s. So when she read that her nearby hospital, Wake Forest Baptist Medical Center, was looking for people with hypertension to volunteer for a study, she quickly signed up, knowing the doctors would monitor her blood pressure more intensively and hopefully lower her risk of developing heart disease and stroke.

What…

Source: TIME: HealthCategory: Consumer Health News Authors: Tags: Uncategorized Aging Alzheimer’s Research Source Type: news

Margaret Daffodil Graham tries to live a healthy life, particularly since she has a health issue that requires constant attention. Like more than 100 million other Americans, the 74-year-old from Winston-Salem, N.C., has high blood pressure, and she has been taking medication to control it since she was in her 30s. So when she read that her nearby hospital, Wake Forest Baptist Medical Center, was looking for people with hypertension to volunteer for a study, she quickly signed up, knowing the doctors would monitor her blood pressure more intensively and hopefully lower her risk of developing heart disease and stroke.

What…

Source: TIME: ScienceCategory: Science Authors: Tags: Uncategorized Aging Alzheimer’s Research Source Type: news

Most people are familiar with the steps they can take to lower their risk of heart disease and cancer. Choosing your diet carefully, exercising and quitting smoking have all been shown to lower the risk of these diseases.
But when it comes to dementia — including dementia related to Alzheimer’s disease — scientists haven’t found many actionable steps that people can take to lower their risk. Genes play a prominent role in who develops dementia, especially Alzheimer’s, and age is also a dominant factor in the degenerative brain disorder, but neither are under human control.
Now, in a presentati…

Source: TIME: HealthCategory: Consumer Health News Authors: Tags: Uncategorized Brain healthytime Source Type: news





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