A breast cancer survivor who ran one of the most notorious brands in fashion is now C.E.O. of Susan G. Komen, working to raise money for a cure.
Publication date: Available online 11 August 2018Source: European Journal of Surgical OncologyAuthor(s): Weikai Xiao, Yutian Zou, Shaoquan Zheng, Xiaoqian Hu, Peng Liu, Xinhua Xie, Ping Yu, Hailin Tang, Xiaoming XieAbstractObjectiveThe impact of primary tumor resection (PTR) on survival is still controversial in stage IV breast cancer. This systematic review and meta-analysis aimed to evaluate the impact of PTR on overall survival (OS) in stage IV breast cancer.MethodsComprehensive literature search was conducted to identify studies comparing PTR with no PTR for stage IV breast cancer. The quality of the studies was assess…
Publication date: 1 November 2018Source: Inorganica Chimica Acta, Volume 483Author(s): Natalia Alvarez, Luis F.S. Mendes, M. Gabriela Kramer, María H. Torre, Antonio J. Costa-Filho, Javier Ellena, Gianella FacchinAbstractIn order to seek for new compounds with antitumor activity, our research group is focused on copper complexes with mixed ligands. This work presents the synthesis and characterization of eight compounds with general formula [Cu(iminodiacetate)(diimine)(H2O)x], with x = 0 or 1, and their cytotoxic activities against tumor cells. The chosen diimine ligands were: 2,2́-dipyridil-amine (bam), 2,2́-…
Authors: Mavriopoulou E, Zampakis P, Smpiliri E, Spyridonidis T, Rapti E, Haberkorn U, Makatsoris T, Apostolopoulos DJ
OBJECTIVE: Single photon emission tomography/computed tomography (SPET/CT) is usually recommended after ambiguous whole body bone scan (WBS) findings. We investigated the value of routine 2-field (“near” whole-body) SPET/CT application in breast cancer (BC) patients.
SUBJECTS AND METHODS: In this prospective study planar WBS and 2-field SPET/CT was performed in 257 consecutive BC patients referred for a bone scan. Whole body scan and SPET/CT were interpreted separately. Addit…
ConclusionThis study confirmed the role of FABP-4 in pathogenesis of type 2 diabetes &breast cancer via enhancing angiogenesis, inflammatory and epigenetic instability biomarkers.
Authors: Shasttiri A, Rostamian Delavar M, Baghi M, Dehghani Ashkezari M, Ghaedi K
PMID: 30092718 [PubMed – as supplied by publisher]
In this study, we elucidated SIRT1 epigenetic role and analyzed the link between the latter and histones H3 and H4 epigenetic marks in all 5 molecular subtypes of breast cancer. Using a cohort of 135 human breast tumors and their matched normal tissues, as well as 5 human-derived cell lines, we identified H3k4ac as a new prime target of SIRT1 in breast cancer. We also uncovered an inverse correlation between SIRT1 and the 3 epigenetic marks H3k4ac, H3k9ac and H4k16ac expression patterns. We showed that SIRT1 modulates the acetylation patterns of histones H3 and H4 in breast cancer. Moreover, SIRT1 regulates its H3 acetylat…
Conclusions: Our study showed that APOBEC3B mRNA expression correlated with sensitivity to NAC in breast cancer patients. In contrast to previous studies, APOBEC3B mRNA expression was not associated with breast cancer prognosis in patients receiving NAC.
PMID: 30093965 [PubMed]
Applying principles taken from the cosmetic plastic surgery lies at the base of any high standard reconstructive surgery in general and oncoplastic breast surgery in particular. The chest wall–based flap is suitable for the reconstruction of a wide range of breast lumpectomy defects and is feasible for small- to medium-sized breasts, which are usually not easily amenable to tissue rearrangement techniques. The learning curve is short, with replicable results.
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No abstract available