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Publication date: Available online 9 July 2018Source: Journal of Biomedical InformaticsAuthor(s): Suhas Vittal, Gokul KarthikeyanAbstractIn the past, algorithms exploiting varying semantics in interactions between biological objects such as genes and diseases have been used in bioinformatics to uncover latent relationships within biological datasets.In this paper, we consider the algorithm Medusa in parallel with binary classification in order to find potential compounds to inhibit oral cancer. Oral cancer affects the mouth and pharynx and has a high mortality rate due to its late discovery. Current methods of oral cancer …
SKIN cancer symptoms are usually distinguishable and one of the most recognised signs is a change in a mole. But another indicator of this type of cancer is a spot or sore. You should see your doctor if you notice these seven changes.
New-onset diabetes mellitus (DM) is one of the first symptoms of pancreatic adenocarcinoma (PDAC). The frequency of endocrine disorders is estimated between 40% and 80% in patients with pancreatic cancer. DM is a risk factor for cancer development but it may also be a consequence of the tumor growth. Data confirming the existence of a relationship between long standing type 2 DM and an increased risk of PDAC comes from numerous clinical studies. Insulin resistance phenomenon and hyperinsulinemia may result in the increased proliferation of pancreatic islets which in turn may cause a predisposition to cancer development. In…
The prevalence of IBS on the US Mexico border is comparable with data obtained from studies in both countries. Consulting a primary care physician as an associated factor may reveal the high rate of health-care seeking in IBS patients, while herbal treatments may reflect a cultural influence.
Stefan Poschner, Alexandra Maier-Salamon, Martin Zehl, Judith Wackerlig, Daniel Dobusch, Anastasia Meshcheryakova, Diana Mechtcheriakova, Theresia Thalhammer, Bettina Pachmann, Walter J äger
Publication date: Available online 10 July 2018Source: Biochimica et Biophysica Acta (BBA) – Reviews on CancerAuthor(s): Niamh Mc Namee, Lorraine O’DriscollAbstractExtracellular vesicles (EVs) including exosomes, microvesicles, oncosomes, and microparticles have been associated with communicating anti-cancer drug-resistance. The in vitro, pre-clinical in vivo and patients’ data linking EVs to drug-resistance (and the specific drugs involved) in breast cancer, prostate cancer, lung cancer, ovarian cancer, haematological malignancies, colorectal cancer, gastric cancer, pancreatic cancer, glioblastoma, neuroblastoma, melanoma…
ConclusionParallel imaging technique can be used with EPI-DWI to increase resolution and decrease geometric distortion artifact to acquire more accurate geometric representation of the acquired anatomy.
Publication date: Available online 9 July 2018Source: The Egyptian Journal of Radiology and Nuclear MedicineAuthor(s): Sarah Mamdouh Osman, Ikram Hamed Mahmoud, Rafaat Mahfouz Riad, Mohamed Hamed ShaabanAbstractAim of workTo study the efficacy of visceral neurolytic blocks in the abdominopelvic cancer when guided by ultrasound/CT.Patients and methods50 patients were selected randomly and prospectively from the pain clinic in NCI suffering from moderate-severe visceral pain (visual analogue score ≥ 4) due to advanced abdominal and pelvic malignancy. Patients were divided into celiac plexus block-CPB (n = 25), superio…
In conclusion, employing protein-drug complexes as stabilizers, Ns with dual payloads are developed and are a promising strategy for co-delivery. Furthermore, the developed Ns can target the tumor microenvironment and cancer cells and, as a result, enable efficient treatment for breast metastatic cancer.Graphical AbstractBy using protein-drug complexes as stabilizers, a platform based on drug nanocrystals with a dual loading of paclitaxel (PTX) and marimastat (MATT) for combined therapy is reported, uncovering a new function for nanocrystals and thus broadening the applications of nanocrystals in drug delivery. The platfor…
Beth O’Brien, 38, of Bennington, Nebraska, was diagnosed with triple-negative breast cancer stage 2 in February 2017.