Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and microorganisms. Fusobacterium nucleatum is among the most prevalent bacterial species in colorectal cancer tissues. Here we show that colonization of human colorectal cancers with Fusobacterium and its associated microbiome—including Bacteroides, Selenomonas, and Prevotella species—is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors. In situ hybridization analysis revealed that Fusobacterium is predominantly associated with cancer cells in the metastatic lesions. Mouse xenografts of human primary colorectal adenocarcinomas were found to retain viable Fusobacterium and its associated microbiome through successive passages. Treatment of mice bearing a colon cancer xenograft with the antibiotic metronidazole reduced Fusobacterium load, cancer cell proliferation, and overall tumor growth. These observations argue for further investigation of antimicrobial interventions as a potential treatment for patients with Fusobacterium-associated colorectal cancer.

Source: ScienceNOWCategory: Science Authors: Tags: Medicine, Diseases reports Source Type: news

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Some women claim the company’s talcum powder caused their ovarian cancer

WOMEN should avoid using talcum powder because of the increased risk of ovarian cancer, a UK charity has warned. The advice comes after a US court ordered pharmaceutical giant Johnson&Johnson to pay damages of £3.6billion to a group of 22 women who blame the company for their condition.

In this study, ultrastable tetraether lipids (TELs) based liposomes were developed. PpIX molecules were identified to reside physically in the monolayer; thereby the inherent π-π stacking that leads to aggregation of PpIX in aqueous milieu was dramatically improved. TEL29.9 mol% and TEL62mol% based liposomes revealed PpIX sustained release diffusion pattern from spherical particles as confirmed by converged fitting to Baker &Lonsdale model. Stability in presence of human serum albumins, a key element for PDT accomplishment was emphasized. The epitome candidates were selected for vascular photodynamic (vPDT…

Source: Drug DeliveryCategory: Drugs & Pharmacology Tags: Drug Deliv Source Type: research

A common drug used to control blood pressure and help prevent heart failure was announced by the US Food and Drug Administration on Friday, a week after 22 other countries recalled it because the drug contains a chemical that poses a potential cancer risk.

Source: – HealthCategory: Consumer Health News Source Type: news

The oral therapy becomes the second androgen receptor-targeting therapy to be approved for use in this earlier disease setting.FDA Approvals

J. Anal. At. Spectrom., 2018, Accepted Manuscript DOI: 10.1039/C8JA00140E, PaperDaria Krauze, Maria Grzelak, Pawel M. Wrobel, Giulia Veronesi, Hiram Castillo-Michel, Lukasz Chmura, Robert Jach, Dariusz Adamek, Marek Lankosz Iron as a trace element plays a role in regulating the homeostasis of the human body and therefore the concentration of iron in the body must be carefully monitored. Both… The content of this RSS Feed (c) The Royal Society of Chemistry

Dalton Trans., 2018, Advance Article DOI: 10.1039/C8DT02408A, CommunicationLai-Hon Chung, Sze-Wing Ng, Chi-Fung Yeung, Hau-Lam Shek, Sheung-Ying Tse, Hoi-Shing Lo, Siu-Chung Chan, Man-Kit Tse, Shek-Man Yiu, Chun-Yuen Wong The first examples of metal –indolizinone complexes prepared by Ru-assisted activation of pyridine-tethered alkynes exhibit moderate cytotoxicity against several human cancer cell lines. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry

We report a novel and easy-to-fabricate polynuclear nanoparticle based on the collaborative re-assembly of nanoparticles as a robust chemogene co-delivery platform. Specifically, the polynuclear nanoparticle carrying DOX and siBcl-2 exerts… The content of this RSS Feed (c) The Royal Society of Chemistry

CONCLUSIONS: Over the years, many improvements have been made on ovarian tissue cultures with the future purpose that patients will be provided with a greater number of developmentally competent oocytes for fertility preservation.
PMID: 29999288 [PubMed – as supplied by publisher]

Source: Minerva GinecologicaCategory: OBGYN Tags: Minerva Ginecol Source Type: research

Prostatitis is an inflammation of the prostate that can cause pain, sexual dysfunction, and urination issues. Chronic prostatitis might last for more than 3 months. Possible causes include bacterial infections and damage to the nerves or muscles in the pelvic area. Treatment often involves antibiotics. Learn more here.

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