Adjuvant capecitabine and gemcitabine followed by radiotherapy and capecitabine was well tolerated and effective in the treatment of extrahepatic cholangiocarcinoma and gallbladder carcinoma. Medscape Medical News

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ConclusionsRLS can be performed for primary hepatobiliary malignancies with long-term oncologic outcomes comparable to published open and laparoscopic data.

AbstractBiliary tract cancer, carcinoma of the extrahepatic bile ducts, carcinoma of the gall bladder, ampullary carcinoma and intrahepatic cholangiocarcinoma are often identified at an advanced stage and have poor prognoses. Although effective chemotherapy regimens are needed, their development remains unsatisfactory. From the results of a phase III clinical trial (ABC-02 trial), gemcitabine plus cisplatin is the standard first-line chemotherapeutic regimen for advanced biliary tract cancer. A phase III trial of gemcitabine plus cisplatin vs. gemcitabine plus S-1 therapy (FUGA-BT) demonstrated the non-inferiority of gemci…

Biliary tract cancer (BTC) or cholangiocarcinoma is a rare cancer worldwide, but prevalent in some areas, where a specific risk factor of environmental exposure is involved in BTC development such as chronic cholangitis[1,2], liver fluke infection in Thailand[1,2], viral hepatitis[1,2], aflatoxin exposure in Chile[3], or other chemical exposure[2,4]. According to its anatomical location, BTCs are mainly classified as intrahepatic (ICC), extra-hepatic bile duct cancer, or gallbladder cancer. The extra-hepatic form is composed of peri-hilar type (PHC or Klatskin tumor) and a distal form (DCC) while gallbladder cancer (GBC) a…

Source: Journal of HepatologyCategory: Gastroenterology Authors: Source Type: research

Malignant biliary obstruction (MBO) is a common condition caused by biliary tract cancer (cholangiocarcinoma, gallbladder carcinoma, or ampulla carcinoma), pancreatic cancer, or metastatic lymph nodes.1 The incidence of MBO is modest in the Western world, although consistently rise; while in East and Southeast Asia, the incidence is remarkably high and poses significant public health issues.2 Surgical excision of detectable tumor is associated with improvemed survival.1 However, less than 20% of patients are surgical candidates once obstructive jaundice has occurred,3 and the long-term survival remains dismal.

Source: Journal of HepatologyCategory: Gastroenterology Authors: Tags: Research Article Source Type: research

In conclusion, 18F-FDG-PET and PET/CT were found to be accurate in the evaluation of primary tumors, lymph node metastasis, and distant metastasis in patients with CCA.

Source: Journal of Investigative MedicineCategory: Research Authors: Tags: Hematology/Oncology Source Type: research

Eur J Pediatr Surg DOI: 10.1055/s-0037-1615275Previous research has confirmed that patients with choledochal cyst have an elevated risk of cholangiocarcinoma and gallbladder carcinoma. Current data suggest a risk of malignancy of 6 to 30% in adults with choledochal cyst. Malignancy has also occasionally been identified in children and adolescents. Multiple factors, including the age of the patient, cyst type, histological findings, and localization, have an impact on the prognosis. Information on long-term outcomes after cyst excision is limited. However, recent data suggest a lifelong elevated risk of up to 4% of cancer d…

Source: European Journal of Pediatric SurgeryCategory: Surgery Authors: Tags: Review Article Source Type: research

ConclusionIt is the most common cancer of gallbladder, gallbladder cancer remains a rare disease. Gallbladder cancer is a rare disease that can be accidentally diagnosed after cholecystectomy or accidentally, often with more advanced disease. The prognosis is generally extremely poor and improvements in surgical resection of this approach have to be re-evaluated, while the role of chemotherapy and radiotherapy remains controversial.

CONCLUSIONS: For recurrent or metastatic BTCs, metastasectomy can be a viable option for selected patients.

Source: Indian Journal of CancerCategory: Cancer & Oncology Authors: Source Type: research

CONCLUSION: The CART-EGFR cell immunotherapy was a safe and active strategy for EGFR-positive advanced BTCs. The enrichment of Tcm in the infused CART-EGFR cells could predict clinical response.
PMID: 29138340 [PubMed – as supplied by publisher]

Source: Clinical Cancer ResearchCategory: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research

CONCLUSIONS: MDCT imaging and post-processing techniques have significant application in the diagnosis of benign and malignant lesions, as well as a malignant tumor of the common bile duct ampulla.
PMID: 28925490 [PubMed – in process]

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