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More than one-third of patients with metastatic uveal melanoma had objective tumor regression when treated with adoptive transfer of autologous tumor-infiltrating lymphocytes.

Source: CancerNetworkCategory: Cancer & Oncology Authors: Tags: Melanoma News Source Type: news

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Conclusion: CCH displays typical findings on SD-OCT. ODR is a new important tool in the differential diagnosis of choroidal tumors and should be considered for enhancing the accuracy of diagnosing CCH. This benefit is especially relevant for cases in which the presentation of CCH is atypical.Ophthalmologica

Source: OphthalmologicaCategory: Opthalmology Source Type: research

BAP1 is a histone deubiquitinase that acts as a tumor and metastasis suppressor associated with disease progression in human cancer. We have used the “Calling Card System” of transposase-directed transposon in…

Source: BMC Medical GenomicsCategory: Genetics & Stem Cells Authors: Tags: Research article Source Type: research

AbstractPurposeUveal melanoma, although a rare form of cancer, is the most common primary malignancy of the eye in adults. Nuclear factor- κB (NF-κB) is a transcription factor that transactivates genes involved in the regulation of cell growth, apoptosis, angiogenesis, and metastasis, but the molecular mechanisms that negatively regulate NF-κB activation are not fully understood. NF-κB can also be activated by DNA damage pathway th rough NEMO protein. Therefore, the objective of this study is to elucidate the role of NEMO/IKKγ protein in uveal melanoma patients.MethodsSeventy-five formalin-fix…

The next in our ” Best of the Month ” series comes from October 9, 2018:Melanoma markers were negative. Smooth muscle markers were positive. This case was determined to be an epithelioid leiomyoma. I didn’t do electron microscopy to look for mitochondia, but it may well be what Ursula Schlotzer-Schredhardt et al. have called a mitochondria-rich epithelioid leiomyoma (Arch Ophthalmol, Vol 120, January 2002).

Source: neuropathology blogCategory: Radiology Tags: Best of the Month series eye ophthalmic pathology Source Type: blogs

Metastatic uveal melanoma (MUM) has a poor prognosis, with no established standard of care. Delineation of prognostic factors in MUM patients may enable stratified treatment algorithms of stage-specific survival. Overall, 132 MUM patients who presented to a single tertiary institution in Toronto, Canada, over 12 years were identified and data (demographics, clinical status, radiographic images, and laboratory values) were extracted. Associations with systemic first-line treatment outcome 12 weeks after first-line treatment, time to progression (TTP), and overall survival (OS) were explored by univariate and multivariable a…

Source: Melanoma ResearchCategory: Cancer & Oncology Tags: ORIGINAL ARTICLES: Clincal research Source Type: research

Uveal melanoma (UM) is a rare form of melanoma without effective therapy. The biology of UM relies on several heat-shock protein 90 (Hsp90)-dependent molecules such as MET, MEK and AKT, making Hsp90 inhibition a rational approach. Patients with stage IV UM, measurable disease, and no previous chemotherapy were eligible. Patients received either ganetespib 200 mg weekly (cohort A) or 150 mg twice a week (cohort B). Primary endpoint response rate (RR) was assessed by RECIST. A total of 17 patients were accrued for this study, with seven in cohort A and 10 in cohort B. Liver metastases were present in 59%. Respo…

Source: Melanoma ResearchCategory: Cancer & Oncology Tags: ORIGINAL ARTICLES: Clincal research Source Type: research

One hundred well-documented cases of uveal melanoma accessioned at the Armed Forces Institute of Pathology before 1970 were reviewed and reclassified to identify changes made in the Callender classification. We compared the new classification with the original classification to determine the effect of the changes on the prediction of outcome for the patient after enucleation. Staff pathologists had originally classified 52 of the 100 cases as spindle-cell type melanoma. Only 31 of the 100 cases were reclassified as spindle-cell types (two spindle-cell nevi and 29 spindle-cell melanomas).

Source: American Journal of OphthalmologyCategory: Opthalmology Authors: Tags: Landmark reprint Source Type: research

Conclusion:
Phakomatosis pigmentovascularis represents coexistence of Klippel–Trenaunay syndrome (or Sturge–Weber syndrome) and oculo(dermal) melanocytosis, promoting risk for life-threatening uveal melanoma. The authors suggest that all patients with Klippel–Trenaunay syndrome be evaluated for phakomatosis pigmentovascularis and affected patients have dilated fundus examination once or twice a year.

Source: RETINACategory: Opthalmology Tags: Original Study Source Type: research

Conclusions:
HAI nab-paclitaxel demonstrates rare objective responses in melanoma patients with liver metastases. This treatment should be studied in combination with checkpoint blockade or other novel treatments to enhance meaningful responses but should not be considered effective monotherapy.

We report an unusual case of an amelanotic melanoma in a 7 year old hispanic child with subclinical globe perforation. Uveal melanoma rarely occurs in children. Young affected patients are mostly light colored eyes caucasians adolescents. Since they are not common, these tumors are usually not recognized and misdiagnose. Differential diagnoses and therapeutic options are outlined.
PMID: 30342820 [PubMed – as supplied by publisher]

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