Rates of colorectal cancer are rising by 6% per year in young adults Related items fromOnMedica Chemicals in green vegetables show to prevent bowel cancer Many trusts not offering genetic bowel cancer test Long-term antibiotic use linked to heightened risk of colorectal adenomas Developing and using a tool to improve outcomes in colorectal cancer Colorectal cancer risk link to ‘inflammatory’ foods
ConclusionThis analysis suggested that when stage and histological type are not specifically considered, serum HE4 is generally a better tool than CA125 in EC diagnosis by its significantly higher sensitivity than CA125.
Conclusions. Taken together, our results showed that the formulation of BSYX had antitumor effect on endometrial cancer in vivo and in vitro and was related with FSH/PI3K/AKT/Gankyrin/HIF-α/cyclinD1 transduction pathway.
PMID: 30402135 [PubMed]
Conclusion: The review showed that anticancer MPs are widely used across the regions of Ethiopia. Most of the MPs are not scientifically experimented and yet are at a higher vulnerability to loss mainly by human activities. Calling for conservation measures, we recommend experimental validation of the frequently used anticancer MPs. This augments global anticancer drug researches.
PMID: 30402131 [PubMed]
Conclusions: SJP is efficient in attenuating HFD induced NAFLD in rats and this effect might be partly related to the inhibition of Akt/mTOR/S6 pathway.
PMID: 30402130 [PubMed]
Authors: Deng J, Wang G, Li J, Zhao Y, Wang X
Background: The invasive pulmonary aspergillosis is a kind of high incidence of disease with difficulties in treatment, poor prognosis, and high mortality.
Objectives: The study aimed to reveal the effect of cinnamaldehyde on the fungal cell wall and verify its efficacy on invasive pulmonary aspergillosis on immunosuppressed Institute of Cancer Research mice (ICR mice).
Methods: ICR mice were given cyclophosphamide 200 mg.kg-1. d-1 by intraperitoneal injection for 2 days. On the 4th day, the mice were given 50 μL of Aspergillosis fumigatus spo…
In this study, we show that ERW treatment of MCF-7, MDA-MB-453, and mouse (TUBO) breast cancer cells inhibited cell survival in a time-dependent fashion. ERW decreased ErbB2/neu expression and impaired pERK1/ERK2 and AKT phosphorylation in breast cancer cells. In addition, ERW treatment induced apoptosis of breast cancer cell lines independently of the status of p53 and ER and PR receptors. Our in vivo results showed that ERW treatment of transgenic BALB-neuT mice delayed the development of mammary tumors compared to the control. In addition, ERW induced a significant prolongation of tumor-free survival and a reduction in …
As a result of better diagnostics and treatment of cancer, the number of survivors is on the rise. Health care needs for female cancer survivors encompass several domains that include surveillance, prevention, management of short/long-term side effects of cancer, and cancer therapy. Primary care health providers (PCHPs) can play an important role in their health care. There is a need for PCHPs to acquire knowledge and understand the complexity involved in caring for this population. They also should be familiar with the guidelines for following cancer survivor patients.
PMID: 30401348 [PubMed – in process]
Publication date: Available online 7 November 2018Source: Life SciencesAuthor(s): Na Xue, Xianwei Wu, Li Wu, Lu Li, Fang WangAbstractInflammation is the vital defensive response triggered by our immune system against an infection or deleterious stimuli. This response in due course affects its own biological system leading to serious diseases like arteriosclerosis, osteoporosis, pancreatitis, cancer etc. Currently, researchers focused on utilizing phytochemicals as anti-inflammatory drugs since the drugs presently available in the market causes serious side effects and are less potent. Flavonoids are polyphenols which impar…
In this study, a constitutive anti-CEACAM5 nanobody expression system was constructed under the control of a glyceraldehyde-3-phosphate dehydrogenase promoter (GAP) promoter. The effects of different carbon sources and pH on nanobody expression were evaluated in shaking flask cultures. After 96 h of constitutive expression in shaking flask, a yield of 51.71 mg/L was obtained. In addition, this constitutive expression system produced nanobodies at equivalent yield and affinity to that produced by methanol-induced expression. The results of this study indicated that the use of a constitutive expression system is a promis…
Publication date: November 2018Source: European Urology Supplements, Volume 17, Issue 13Author(s): J. Marzec, J. Becker, F. Paulsen, D. Wegener, S.-C. Olthof, C. Pfannenberg, K. Nikolaou, J. Schwenck, C. La Fougère, D. Zips, A.-C. Müller