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Experimental off-the-shelf cell therapies against cancer and long-term viral infections were grabbed by Atara Biotherapeutics Inc. in a licensing deal with Memorial Sloan Kettering Cancer Center.

South San Francisco’s Atara (NASDAQ: ATRA) — part of the San Francisco Business Times’ life sciences IPO Class of 2014 — said Monday that it licensed three programs already in clinical trials that boost the body’s ability to fight Epstein Barr Virus, or EBV, cytomegalovirus and Wilms Tumor 1, or WT1.…

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Conclusion:
This study reports for the first time an association between IFNL3/4 polymorphisms and susceptibility to AIDS-related Kaposi’s sarcoma.

Source: AIDSCategory: Infectious Diseases Tags: CONCISE COMMUNICATION Source Type: research

Conclusion:
HPV16 prevalence is lower in African American compared with Caucasian women with HIV and cervical precancer, independent of immune status. Future studies to determine why these racial differences exist are warranted, and whether there are similar associations between race and invasive cervical cancer in women with HIV. Further, HPV types not covered by quadrivalent and bivalent vaccines may play an especially important role in cervical precancer among HIV-positive African American women, a possible advantage to using nonavalent HPV vaccine in this population.

Source: AIDSCategory: Infectious Diseases Tags: CONCISE COMMUNICATIONS Source Type: research

This study aimed to validate the synergistic effect of ABT-737 on docetaxel using MDA-MB-231, a triple negative breast cancer (TNBC) cell line overexpressing B-cell lymphoma-2 (Bcl-2).
Methods: Western blot analysis was performed to assess expression levels of Bcl-2 family proteins and caspase-related molecules. Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cycle distribution was determined by flow cytometry analysis. Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (z-VAD-fmk) was used for pretreatment to assess the role of caspases.
Results: Cel…

ConclusionHashimoto’s thyroiditis is associated with significantly increased risk of developing thyroid carcinoma, especially thyroid microcarcinoma.ResumoIntroduçãoA relação entre a tireoidite de Hashimoto e o carcinoma de tireoide tem sido um tema de controvérsia por um longo tempo.ObjetivoDeterminar a prevalência da coexistência de carcinoma de tireoide e tireoidite de Hashimoto no exame histopatológico de amostras de pacientes tireoidectomizados.MétodoEm um estudo retrospectivo, foram analisados os dados clinico-histopatológicos de 2.117 pacientes (1.7…

ConclusionsacRoots inhibited the malignant biological behavior of HCC cells via regulation of the epithelial-mesenchymal transition (EMT) by DLX2.Graphical abstract

Abstract
The serine/threonine phosphatase PP2A regulates a vast portion of the phosphoproteome including pathways involved in apoptosis, proliferation and DNA damage response and PP2A inactivation is a vital step in malignant transformation. Many groups have explored the therapeutic venue of combining PP2A reactivation with kinase inhibition to counteract the very changes in tumor suppressors and oncogenes that lead to cancer development. Conversely, inhibition of PP2A to complement chemotherapy and radiation-induced cancer cell death is also an area of active investigation. Here we review the studies that utilize…

Source: Molecular MedicineCategory: Molecular Biology Authors: Tags: Biochim Biophys Acta Mol Cell Res Source Type: research

Xu Wang, Lin Qiu, Ziyi Li, Xiang-Yang Wang, Huanfa Yi

Conclusion: The Wnt/ β-catenin pathway plays a vital role in aspirin-induced apoptosis by regulating mitochondrial/caspase-3 function. Elevating COX-2 levels may protect cells against apoptosis. More importantly, the results remind us to consider the apoptotic effect of aspirin on TSCs and tendon cells when aspirin is administered to treat tendinopathy. The relationship between the positive and negative effects of aspirin remains a subject for future study.Cell Physiol Biochem 2018;50:2046 –2059

Authors: Wende K, Woedtke TV, Weltmann KD, Bekeschus S
Abstract
Reactive oxygen and nitrogen species deposited by cold physical plasma are proposed as predominant effectors in the interaction between discharge and biomedical application. Most reactive species found in plasma sources are known in biology for inter- and intracellular communication (redox signaling) and mammalian cells are equipped to interpret the plasma derived redox signal. Such, considerable effort has been put on the investigation of potential clinical applications and the underlying mechanism, with a special emphasis on conditions orchestrated s…

Source: Biological ChemistryCategory: Chemistry Tags: Biol Chem Source Type: research

CONCLUSIONS: The present three cases add further evidence that secukinumab is effective and well tolerated in difficult to treat psoriatic patients with multiple comorbidities, namely HBV, latent TBC infection, and hepatic impairment.
PMID: 30403898 [PubMed – as supplied by publisher]

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