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This is the first drug ever to be approved for the treatment of Waldenstrom’s macroglobulinemia since the disease was described 70 years ago. FDA Approvals

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AbstractBruton ’s tyrosine kinase (BTK) is crucial in B-cell development and survival. The role of BTK as a downstream kinase in the B-cell receptor (BCR) signaling pathway is well described. As a key player in the pathogenesis of B-cell malignancies, targeting of dysregulated BCR signaling has been explored by development of inhibitors of downstream mediators. Discovery of the biological function of BTK and the development of covalent inhibitors for clinical use, ibrutinib as the lead agent and acalabrutinib as the second clinically approved BTK inhibitor, have revolutionized the treatment options for B-c ell malign…

Source: DrugsCategory: Drugs & Pharmacology Source Type: research

No abstract available

Source: Journal of Thoracic ImagingCategory: Radiology Tags: Web Exclusive Content-JSTR Meeting Notes Source Type: research

British Journal of Haematology, EarlyView.

Source: British Journal of HaematologyCategory: Hematology Authors: Source Type: research

Publication date: Available online 17 October 2018Source: Biochimica et Biophysica Acta (BBA) – General SubjectsAuthor(s): Sana Batool, Kimon V. Argyropoulos, Roksana Azad, Precious Okeoma, Hasan Zumrut, Sanam Bhandari, Rigzin Dekhang, Prabodhika R. MallikaratchyAbstractNucleic Acid Aptamers (NAAs) are a class of synthetic DNA or RNA molecules that bind specifically to their target. We recently introduced an aptamer termed R1.2 against membrane Immunoglobulin M (mIgM) expressing B-cell neoplasms using Ligand Guided Selection (LIGS). While LIGS-generated aptamers are highly specific, their lower affinity prevents aptamers f…

We report our single institution experience, and describe five cases with distinctive glomerular pathology: intracapillary IgM pseudothrombi and thrombotic microangiopathic change, with glomerular intracellular crystals in two biopsies. Two patients were hypocomplementemic at presentation. This series adds to the recent literature on paraprotein associated thrombotic microangiopathy.
PMID: 30334170 [PubMed – as supplied by publisher]

Source: Journal of NephrologyCategory: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research

Conclusion: We present a single-center experience of 22 patients with LPL, including a non-IgM cohort, in Korea. The treatment of non-IgM LPL was heterogeneous, and patients with non-IgM LPL showed a higher 5-year mortality rate and more adverse prognostic factors than those with LPL/WM.
PMID: 30310784 [PubMed]

Source: Blood ResearchCategory: Hematology Tags: Blood Res Source Type: research

This study assessed differentially expressed genes (DEGs) to identify potential WM biomarkers and uncover the underlying the molecular mechanisms of WM progression us ing gene expression profiles from the Gene Expression Omnibus database. DEGs were identified using the LIMMA package and their potential functions were then analyzed by using the gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses and the protein-protein intera ction (PPI) network analysis by using the Search Tool for the Retrieval of Interacting Genes/Proteins database. Data showed that among 1,756 DEGs, 926 were upregu…

This study assessed differentially expressed genes (DEGs) to identify potential WM biomarkers and uncover the underlying the molecular mechanisms of WM progression using gene expression profiles from the Gene Expression Omnibus database. DEGs were identified using the LIMMA package and their potential functions were then analyzed by using the gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses and the protein-protein interaction (PPI) network analysis by using the Search Tool for the Retrieval of Interacting Genes/Proteins database. Data showed that among 1,756 DEGs, 926 were upregula…

Source: Acta HaematologicaCategory: Hematology Authors: Tags: Acta Haematol Source Type: research

ConclusionvWF levels measured in the serum could become an important prognostic marker in patients with WM and requires further investigation.

British Journal of Haematology, EarlyView.

Source: British Journal of HaematologyCategory: Hematology Authors:

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