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The Queen Mary University of London study, on more than 50,000 women, also found that 47 per cent lower risk of dying from breast cancer within 20 years after diagnosis.

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This study aimed to validate the synergistic effect of ABT-737 on docetaxel using MDA-MB-231, a triple negative breast cancer (TNBC) cell line overexpressing B-cell lymphoma-2 (Bcl-2).
Methods: Western blot analysis was performed to assess expression levels of Bcl-2 family proteins and caspase-related molecules. Cell viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cycle distribution was determined by flow cytometry analysis. Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone (z-VAD-fmk) was used for pretreatment to assess the role of caspases.
Results: Cel…

CONCLUSIONS: The present three cases add further evidence that secukinumab is effective and well tolerated in difficult to treat psoriatic patients with multiple comorbidities, namely HBV, latent TBC infection, and hepatic impairment.
PMID: 30403898 [PubMed – as supplied by publisher]

Improved relapse-free survival on aromatase inhibitors in breast cancer is associated with interaction between oestrogen receptor-α and progesterone receptor-bImproved relapse-free survival on aromatase inhibitors in breast cancer is associated with interaction between oestrogen receptor-α and progesterone receptor-b, Published online: 09 November 2018; doi:10.1038/s41416-018-0331-3Improved relapse-free survival on aromatase inhibitors in breast cancer is associated with interaction between oestrogen receptor-α and progesterone receptor-b

Source: British Journal of CancerCategory: Cancer & Oncology Authors: Source Type: research

AbstractA novel treatment planning framework, the Relative Biological Effective Dose (RBED), for high Z nanoparticle (NP)-enhanced photon radiotherapy is developed and tested in silico for the medical exemplar of neoadjuvant (preoperative) breast cancer MV photon radiotherapy. Two different treatment scenarios, conventional and high Z NP enhanced, were explored with a custom Geant4 application that was developed to emulate the administration of a single 2 Gy fraction as part of a 50 Gy radiotherapy treatment plan. It was illustrated that there was less than a 1% difference in the dose deposition throughout the standard and…

Conclusion: The review showed that anticancer MPs are widely used across the regions of Ethiopia. Most of the MPs are not scientifically experimented and yet are at a higher vulnerability to loss mainly by human activities. Calling for conservation measures, we recommend experimental validation of the frequently used anticancer MPs. This augments global anticancer drug researches.
PMID: 30402131 [PubMed]

In this study, we show that ERW treatment of MCF-7, MDA-MB-453, and mouse (TUBO) breast cancer cells inhibited cell survival in a time-dependent fashion. ERW decreased ErbB2/neu expression and impaired pERK1/ERK2 and AKT phosphorylation in breast cancer cells. In addition, ERW treatment induced apoptosis of breast cancer cell lines independently of the status of p53 and ER and PR receptors. Our in vivo results showed that ERW treatment of transgenic BALB-neuT mice delayed the development of mammary tumors compared to the control. In addition, ERW induced a significant prolongation of tumor-free survival and a reduction in …

Condition:   HER2 Positive Breast Cancer Intervention:   Drug: Pyrotinib plus trastuzumab and docetaxel Sponsor:   Henan Cancer Hospital Not yet recruiting

Source: ClinicalTrials.govCategory: Research Source Type: clinical trials

Condition:   Breast Cancer Interventions:   Drug: Apatinib;   Drug: Paclitaxel;   Drug: Carboplatin Sponsor:   Chinese Academy of Medical Sciences Recruiting

Source: ClinicalTrials.govCategory: Research Source Type: clinical trials

This study sought to determine the prevalence of American Heart Association/American College of Cardiology Foundation (AHA/ACCF) heart failure (HF) Stages after potentially cardiotoxic chemotherapy was initiated.BackgroundFor individuals receiving potentially cardiotoxic chemotherapy, the frequency of transitioning from Stage A to more advanced HF Stages is not well described.MethodsIn 143 Stage A HF patients with breast cancer, lymphoma and leukemia, renal cell carcinoma, or sarcoma prior to and then at 3, 6, and 12 to 24 months after potentially cardiotoxic chemotherapy was initiated, we obtained blinded cardiac mag…

Retraction Note: Inhibition of hTERT Gene Expression by SilibininLoaded PLGA-PEG-Fe₃O₄ in T47D Breast Cancer Cell Line.
Bioimpacts. 2018;8(4):321
Authors: Ebrahimnezhad Z, Zarghami N, Keyhani M, Amirsaadat S, Akbarzadeh A, Rahmati M, Mohammad Taheri Z, Nejati-Koshki K
Abstract
[This retracts the article DOI: 10.5681/bi.2013.005.].
PMID: 30397586 [PubMed – in process]

Source: BioImpactsCategory: Research Tags: Bioimpacts Source Type: research

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