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Yohimbine
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Case Study: Two Fatal Case Reports of Acute Yohimbine Intoxication. Anderson C et al.  J Anal Toxicol 2013;37:611-614.
Abstract
This paper reports 2 medical examiner cases in which death was attributed to yohimbine overdose on the basis of extremely high post-mortem levels and no other apparent contributing factor. Although the article will be of most interest to forensic pathologists and toxicologists, it does give us the opportunity to review briefly the pharmacology and toxicology of the drug.
Yohimbine is derived from the bark of a West African evergreen. It is an alpha-2 blocker, and thus has actions somewhat opposite to those of clonidine (an alpha-2 agonist). It is available by prescription (Yocon, Aphrodyne, Erex, Testomar) and also over-the-counter in “natural” or health store preparations.
Although benefits have not been proven, yohimbine is used as an aphrodisiac and to treat erectile dysfunction. It increases release of norepinephrine and dopamine, and acts as a CNS stimulant and vasodilator. Its effects are increased by common co-ingestants such as caffeine.
Manifestations of yohimbine overdose include nausea, agitation, anxiety, hypertension, diaphoresis, mydriasis, priapism and bronchospasm. Generally, overdose patients respond to supportive care and benzodiazepines as needed. Clonidine has been used to treat yohimbine-associated hypertension.
Related post:
Yohimbe and Priapism

Source: The Poison ReviewCategory: Toxicology Authors: Tags: Medical aphrodisiac yohimbine overdose Source Type: news

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Source: AIDSCategory: Infectious Diseases Tags: EDITORIAL REVIEW Source Type: research

Background:
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Methods:
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Source: AIDSCategory: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research

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Purpose of review
Various neurologically focused monitoring modalities such as processed electroencephalography (pEEG), tissue/brain oxygenation monitors (SbO2), and even somatosensory evoked responses have been suggested as having the potential to improve the well tolerated and effective delivery of care in the setting of outpatient surgery. The present article will discuss the pros and cons of such monitors in this environment.
Recent findings
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Purpose of review
Ambulatory procedural sedation is used to relieve anxiety, pain and discomfort in a broad spectrum of patients during many types of diagnostic or therapeutic procedures. This review focuses on recent comparative studies of commonly used and new drugs for adult ambulatory sedation.
Recent findings
Midazolam and propofol are commonly used for ambulatory sedation. Their pharmacological properties offer many advantages and there is much experience with their use. Ketamine can be a useful addition to hypnotic drugs but the advantage of the use of ketofol (a mixture of propofol and ketamine) is, although o…

HIGH BLOOD pressure can be caused by eating a diet which is high in salt. Not adding salt to meals is an obvious way to cut down on it, but sometimes it can be hidden in some unlikely foods. Limit your intake of these four foods to help lower your blood pressure.

CONCLUSIONS: The present three cases add further evidence that secukinumab is effective and well tolerated in difficult to treat psoriatic patients with multiple comorbidities, namely HBV, latent TBC infection, and hepatic impairment.
PMID: 30403898 [PubMed – as supplied by publisher]

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Authors: Kwon I, Jun DW, Moon JH
Abstract
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Source: Gut and LiverCategory: Gastroenterology Tags: Gut Liver Source Type: research

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PMID: 30402871 [PubMed – in process]

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