This study confirms a previously reported association between high birth weight and the risk of developing childhood acute lymphoblastic leukemia. How might this relate to ethnicity and maternal diet?Southern Medical Journal
We present a case of an infant who developed pro-B acute lymphoblastic leukemia with a rare and complex MLL-translocation. Cytogenetic analysis of bone marrow cells at diagnosis showed a 46,XY,t(X;11)(p11.2;q23)/46,XY karyotype. Fluorescence in situ hybridization analysis using a break apart specific probes showed a split in the MLL gene. Long distance inverse-PCR and next generation sequencing analysis depicted a complex rearrangement t(X;11;17)(p11.2;q23;q12) involving MLL, MLLT6 and the genomic region Xp11.23, 41 bases upstream of the WDR45 gene. WDR45 encodes a beta-propeller protein essential for autophagocytos…
Conclusion: Aberrant CD79a and/or PAX5 expression can be found in AML cases withRUNX1 mutations even without the translocation t(8; 21). Our series shows the expression of CD79a and PAX5 to be a potential pitfall in the classification ofRUNX1 mutant acute leukemia.Pathobiology
An in vitrodiagnostic test was recently approved to detect minimal residual disease in patients with acute lymphoblastic leukemia (ALL) or multiple myeloma.
Hematological Oncology,Volume 0, Issue ja, -Not available-.
American Journal of Hematology,Volume 0, Issue ja, -Not available-.
Conclusion: The current study was designed to focus on the allosteric regulation (autoinhibition) of the of Shp2 protein. Subsequently, it will cover the last 10-year recap of Shp2 protein, their role in cancer, and regulation in numerous ways (allosteric regulation).
PMID: 30398108 [PubMed – as supplied by publisher]
Of the 3,100 children diagnosed with acute lymphoblastic leukemia (ALL) in the U.S. each year , approximately 10% will ultimately succumb to their disease [2,3]. Prognosis is far worse for the>3,000 U.S. adults diagnosed annually, with only about 30-40% 5-year overall survival among this cohort [4,5]. Nearly 1 in 10 adults will never even achieve remission, and more than half of those who do will go on to suffer relapse and disease-related mortality .
Journal of Cellular Biochemistry, EarlyView.
Rearrangements of the mixed-lineage-leukemia (MLL) gene at chromosome 11q23 are frequently observed in infantile acute lymphoblastic leukemia (ALL) and therapy-related second leukemia [1,2], and ALL with MLL gene rearrangements (MLL+ALL) is refractory to chemotherapy and its prognosis is still dismal although it has been improved to some extent by performing hematopoietic stem cell transplantation [3,4]. Of interest, MLL+ALL has a unique gene profile clearly distinguishable from other types of ALL and acute myeloid leukemia (AML), and specific genes such as Fms-like tyrosine kinase 3 (FLT3), CD44, LMO2, and HOXA9 are overe…
Cancer Science,Volume 0, Issue ja, -Not available-.