This study confirms a previously reported association between high birth weight and the risk of developing childhood acute lymphoblastic leukemia. How might this relate to ethnicity and maternal diet?Southern Medical Journal

Source: Medscape Today HeadlinesCategory: Consumer Health News Tags: Ob/Gyn & Women ‘ s Health Journal Article Source Type: news

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We present a case of an infant who developed pro-B acute lymphoblastic leukemia with a rare and complex MLL-translocation. Cytogenetic analysis of bone marrow cells at diagnosis showed a 46,XY,t(X;11)(p11.2;q23)[13]/46,XY[7] karyotype. Fluorescence in situ hybridization analysis using a break apart specific probes showed a split in the MLL gene. Long distance inverse-PCR and next generation sequencing analysis depicted a complex rearrangement t(X;11;17)(p11.2;q23;q12) involving MLL, MLLT6 and the genomic region Xp11.23, 41 bases upstream of the WDR45 gene. WDR45 encodes a beta-propeller protein essential for autophagocytos…

Source: Cancer GeneticsCategory: Cancer & Oncology Source Type: research

Conclusion: Aberrant CD79a and/or PAX5 expression can be found in AML cases withRUNX1 mutations even without the translocation t(8; 21). Our series shows the expression of CD79a and PAX5 to be a potential pitfall in the classification ofRUNX1 mutant acute leukemia.Pathobiology

Source: PathobiologyCategory: Pathology Source Type: research

An in vitrodiagnostic test was recently approved to detect minimal residual disease in patients with acute lymphoblastic leukemia (ALL) or multiple myeloma.

Source: JAMACategory: General Medicine Source Type: research

Hematological Oncology,Volume 0, Issue ja, -Not available-.

Source: Hematological OncologyCategory: Hematology Authors: Source Type: research

American Journal of Hematology,Volume 0, Issue ja, -Not available-.

Source: American Journal of HematologyCategory: Hematology Authors: Source Type: research

Conclusion: The current study was designed to focus on the allosteric regulation (autoinhibition) of the of Shp2 protein. Subsequently, it will cover the last 10-year recap of Shp2 protein, their role in cancer, and regulation in numerous ways (allosteric regulation).
PMID: 30398108 [PubMed – as supplied by publisher]

Source: Current Pharmaceutical DesignCategory: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research

Of the 3,100 children diagnosed with acute lymphoblastic leukemia (ALL) in the U.S. each year [1], approximately 10% will ultimately succumb to their disease [2,3]. Prognosis is far worse for the>3,000 U.S. adults diagnosed annually, with only about 30-40% 5-year overall survival among this cohort [4,5]. Nearly 1 in 10 adults will never even achieve remission, and more than half of those who do will go on to suffer relapse and disease-related mortality [6].

Source: Leukemia ResearchCategory: Hematology Authors: Source Type: research

Journal of Cellular Biochemistry, EarlyView.

Source: Journal of Cellular BiochemistryCategory: Biochemistry Authors: Source Type: research

Rearrangements of the mixed-lineage-leukemia (MLL) gene at chromosome 11q23 are frequently observed in infantile acute lymphoblastic leukemia (ALL) and therapy-related second leukemia [1,2], and ALL with MLL gene rearrangements (MLL+ALL) is refractory to chemotherapy and its prognosis is still dismal although it has been improved to some extent by performing hematopoietic stem cell transplantation [3,4]. Of interest, MLL+ALL has a unique gene profile clearly distinguishable from other types of ALL and acute myeloid leukemia (AML), and specific genes such as Fms-like tyrosine kinase 3 (FLT3), CD44, LMO2, and HOXA9 are overe…

Source: Leukemia ResearchCategory: Hematology Authors: Tags: Research paper Source Type: research

Cancer Science,Volume 0, Issue ja, -Not available-.

Source: Cancer ScienceCategory: Cancer & Oncology Authors: Source Type: research


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