(MedPage Today) — Decreased survival also observed, but study limitations prevent causality
Condition: Prediction by the Synek Score of Poor Neurological Outcome in Postanoxic Comatose Patients Treated With Induced Hypothermia Intervention: Procedure: induced hypothermia Sponsor: Centre Hospitalier Universitaire, Amiens Completed
Neuroprotective cold-shock proteins (CSPs) are abundant in the normothermic neonatal rodent brain but decrease with advancing neurodevelopmental age and are low or absent in the adult brain. It has not been established if neurodevelopmental age alters the baseline expression of CSPs in the human brain. Here, we tested the hypothesis that protein levels of RNA-binding motif 3 (RBM3), reticulon-3 (RTN3), and cold-induced RNA-binding protein (CIRBP) are abundant in the normothermic developing human brain but low-to-absent in adults. We also tested if β-klotho (KLB) is expressed in the developing brain; KLB functions as a…
We thank Mr. Wood and Mr. Podsialdo for their insightful comments regarding the Pragmatic Airway Resuscitation Trial (PART) results.
With regards to their comment of prior studies finding better outcomes with intubation than supraglottic airways, one must bear in mind that these prior studies were biased by their retrospective designs; the airway was selected by paramedic choice and may have been influenced by a range of factors such as the patient’s condition, anatomy, the physical environment or the practitioner’s level of comfort. Meta-analysis or systematic reviews of these retrospective studies …
Medical device developer Hypothermia Devices has raised $10.7 million in a new round of equity financing, according to a recently posed SEC filing.
Money in the round came from 51 anonymous sources with the first sale dated on March 21, according to the filing.
Los Angeles-based Hypothermia Devices is designing and manufacturing cooling and heating devices for medical applications including therapeutic hypothermia, according to the company’s website.
The company’s devices are portable, battery operated and are intended for use as both emergency equipment in ambulances and healthcare facilities.
ConclusionEarly MRIs were technically feasible while maintaining hypothermic goal temperatures in infants with HIE. Cerebral oxygen metabolism early during hypothermia is more disturbed in severe HIE. In infants with moderate HIE, cerebral blood flow decreased and oxygen extraction fraction increased between early and post-hypothermia scans. A comparison of cerebral oxygen metabolism parameters between early and post-hypothermia MRIs might improve our understanding of the evolution of HIE and the benefits of hypothermia. This approach could guide the use of adjunctive neuroprotective strategies in affected infants.
Condition: Cesarean Section Intervention: Device: zero flux skin termometer Sponsor: Oslo University Hospital Not yet recruiting
Publication date: Available online 3 November 2018Source: Journal of Clinical NeuroscienceAuthor(s): Aimalohi Esechie, Anish Bhardwaj, Todd Masel, Mukaila RajiAbstractElderly individuals are a fast-rising segment of the US population and are at high risk of permanent disability and premature death secondary to traumatic injuries such as burn injury. The current paper will review the extant literature to understand the prevalence of burn injury in the elderly, the neurocognitive complications unique to the aged that places this cohort at risk, and evidence-based recommendations to reduce the early and late neurocognitive ef…
CONCLUSION: We propose a treatment protocol based on a sequential combination of anaesthetics, anti-epileptic drugs and alternative therapies. Strategies to evaluate treatment response and to wean drugs based on clinical results are also proposed.
PMID: 30387431 [PubMed – in process]
AbstractThe present study aimed to determine whether postmortem period, physical constitution, cause of death, and cardiopulmonary resuscitation are associated with positional changes in the postmortem appearance of conjunctival petechiae. We retrospectively investigated serial forensic autopsies from 6 h to 6 days postmortem (n = 442; male, 303; female, 139; median age, 62 years; range, 0–100 years). The causes of death were sharp instrument injury, blunt force trauma, fire, intoxication, asphyxia, drowning, hypothermia, hyperthermia, acute heart failure, and natural causes. Of the…
This study examines the relationship between clinical predictors, …