Women who had radiotherapy for Wilms tumor face an increased risk of early breast cancer, according to results from National Wilms Tumor Late Effects Study. Reuters Health Information
In conclusion, our findings demonstrate that WT1 isoforms play different roles in modulating the VM-forming capacity and metastatic potential of TNBC cells.
PMID: 29024629 [PubMed – indexed for MEDLINE]
CONCLUSIONS: The second malignancies in this cohort affected overall survival and suggest the possibility of other germline mutations in addition to BRCA2 in male patients with breast cancer.
PMID: 28122723 [PubMed – as supplied by publisher]
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Abstract The gene encoding Sal-like 4 (Drosophila) (SALL4) is a zinc-finger transcriptional factor and a vertebrate orthologous of the Drosophila gene spalt (sal), which is upregulated in some cancers. SALL4 is expressed in the early developmental stages of Drosophila. Moreover, murine SALL4 plays a vital role in protecting the properties of embryonic stem (ES) cells and guiding the outcome of the primal inner cell mass by interacting with OCT4 and NANOG. SALL4 in ES cells and tumor cells is known as a regulator for controlling cell growth, proliferation, and apoptosis. However, the downstream goals of SALL4 remain largel…
More than 70% of children with stage IV, favorable histology (FH) Wilms tumor will be relapse‐free survivors 16 years after diagnosis. Successful treatment generally includes whole lung radiation therapy and doxorubicin. Such therapy is associated with adverse, long‐term effects, including impaired pulmonary function, congestive heart failure, and second malignant neoplasms, especially breast cancer. Cooperative groups have adopted a risk‐based approach to the treatment of these patients. It is important to recall the good overall prognosis for this group before recommendations for intensification are made based on p…
Authors: Fernandez-Pineda I, Sandoval JA, Davidoff AM
The management of hepatic metastatic disease from solid tumors in adults has been extensively described and resection of metastatic liver lesions from colorectal adenocarcinoma, renal adenocarcinoma, breast cancer, testicular cancer, and neuroendocrine tumors (NET) have demonstrated therapeutic benefits in select patients. However, there are few reports in the literature on the management of hepatic metastatic disease in the pediatric and adolescent populations and the effectiveness of hepatic metastasectomy. This may be due to the much lower incidence …
Doxorubicin (Dox) is an FDA approved chemotherapeutic drug of the cell cycle non-specific class of drugs: the anthracycline antitumor antibiotics. Doxorubicin is commonly used to treat many types of cancer including leukemia, lymphoma, neuroblastoma, sarcoma, and Wilms’ tumor as well as cancers of the lung, breast, stomach, ovary, thyroid, and bladder. In the treatment of breast cancer (BCa), Dox is highly effectively in early-stage as well as advanced-stage tumors, administered as single-drug or combination therapy [1–5].