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Janssen Biotech and Pharmacyclics have received approval from the US Food and Drug Administration (FDA) for Imbruvica (ibrutinib) capsules as the first therapy indicated specifically for patients with Waldenström’s macroglobulinemia (WM), a rare, ind…

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British Journal of Haematology, EarlyView.

Source: British Journal of HaematologyCategory: Hematology Authors: Tags: Correspondence Source Type: research

British Journal of Haematology, EarlyView.

Source: British Journal of HaematologyCategory: Hematology Authors: Tags: Images in Haematology Source Type: research

AbstractBruton ’s tyrosine kinase (BTK) is crucial in B-cell development and survival. The role of BTK as a downstream kinase in the B-cell receptor (BCR) signaling pathway is well described. As a key player in the pathogenesis of B-cell malignancies, targeting of dysregulated BCR signaling has been explored by development of inhibitors of downstream mediators. Discovery of the biological function of BTK and the development of covalent inhibitors for clinical use, ibrutinib as the lead agent and acalabrutinib as the second clinically approved BTK inhibitor, have revolutionized the treatment options for B-c ell malign…

Source: DrugsCategory: Drugs & Pharmacology Source Type: research

No abstract available

Source: Journal of Thoracic ImagingCategory: Radiology Tags: Web Exclusive Content-JSTR Meeting Notes Source Type: research

British Journal of Haematology, EarlyView.

Source: British Journal of HaematologyCategory: Hematology Authors: Source Type: research

Publication date: Available online 17 October 2018Source: Biochimica et Biophysica Acta (BBA) – General SubjectsAuthor(s): Sana Batool, Kimon V. Argyropoulos, Roksana Azad, Precious Okeoma, Hasan Zumrut, Sanam Bhandari, Rigzin Dekhang, Prabodhika R. MallikaratchyAbstractNucleic Acid Aptamers (NAAs) are a class of synthetic DNA or RNA molecules that bind specifically to their target. We recently introduced an aptamer termed R1.2 against membrane Immunoglobulin M (mIgM) expressing B-cell neoplasms using Ligand Guided Selection (LIGS). While LIGS-generated aptamers are highly specific, their lower affinity prevents aptamers f…

We report our single institution experience, and describe five cases with distinctive glomerular pathology: intracapillary IgM pseudothrombi and thrombotic microangiopathic change, with glomerular intracellular crystals in two biopsies. Two patients were hypocomplementemic at presentation. This series adds to the recent literature on paraprotein associated thrombotic microangiopathy.
PMID: 30334170 [PubMed – as supplied by publisher]

Source: Journal of NephrologyCategory: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research

American Journal of Hematology, EarlyView.

Vasoproliferative retinopathy secondary to Waldenström’s disease.
Arch Soc Esp Oftalmol. 2018 Oct 11;:
Authors: Espinosa-Barberi G, Galván González FJ, Miranda Fernández S, Viera Peláez D, Medina Rivero F, Marrero Saavedra D
Abstract
A 66 year-old patient, monitored for diabetic retinopathy refractory to multiple treatment methods despite a good metabolic control, referred to progressive weight loss. For this reason, a systemic study was performed, detecting anaemia, elevation of the erythrocyte sedimentation rate, and hyperproteinaemia due to elevated serum levels of m…

Conclusion: We present a single-center experience of 22 patients with LPL, including a non-IgM cohort, in Korea. The treatment of non-IgM LPL was heterogeneous, and patients with non-IgM LPL showed a higher 5-year mortality rate and more adverse prognostic factors than those with LPL/WM.
PMID: 30310784 [PubMed]

Source: Blood ResearchCategory: Hematology Tags: Blood Res Source Type: research

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