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The warning comes as women in the U.S. pursue morcellator lawsuits after allegedly experiencing the spread of uterine sarcoma and other cancers due to uterine morcellation.(PRWeb December 16, 2014)Read the full story at http://www.prweb.com/releases/morcellator-lawsuit/morcellator-cancer/prweb12399400.htm

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In conclusion, some of the 5-oxo-hexahydroquinoline derivatives are effective efflux pump inhibitors capable of simultaneously blocking 3 important ABC transporters involved in MDR, and represent promising agents to overcome MDR in cancer cells.
PMID: 30391378 [PubMed – as supplied by publisher]

Source: Toxicology and Applied PharmacologyCategory: Toxicology Authors: Tags: Toxicol Appl Pharmacol Source Type: research

Conclusion:BCOR-ITDs define a rare subset of pediatric sarcomas and clinically aggressive endometrial stromal sarcoma cases, as defined by NGS for the first time. Our findings help delineate the pan-cancer landscape of this alteration and suggest the need for focused investigation to delineate the pro-oncogenic function ofBCOR, along with any sensitivity to targeted therapies.Oncology

Source: OncologyCategory: Cancer & Oncology Source Type: research

CONCLUSION: BCOR-ITDs define a rare subset of pediatric sarcomas and clinically aggressive endometrial stromal sarcoma cases, as defined by NGS for the first time. Our findings help delineate the pan-cancer landscape of this alteration and suggest the need for focused investigation to delineate the pro-oncogenic function of BCOR, along with any sensitivity to targeted therapies.
PMID: 30380541 [PubMed – as supplied by publisher]

Source: OncologyCategory: Cancer & Oncology Authors: Tags: Oncology Source Type: research

ConclusionsOur study suggests that patients with LPM for presumed leiomyomas appear to have a considerable risk of unexpected cancers. Moreover, morcellation is potentially associated with adverse prognosis in patients with high-grade sarcomas. Informed consent on unexpected cancers that should be discussed before morcellation.

ConclusionsOur study suggests that patients with LPM for presumed leiomyomas appear to have a considerable risk of unexpected cancers. Moreover, morcellation is potentially associated with adverse prognosis in patients with high-grade sarcomas. Informed consent on unexpected cancers that should be discussed before morcellation.

This study aimed to assess the expression profile of 84 cancer-related miRNAs and to evaluate their correlation with clinical pathological features. Eighty-two formalin-fixed paraffin-embedded (FFPE) samples were selected. In leiomyosarcoma (LMS), there was an association of lower cancer-specific survival (CSS) with the downregulation of miR-125a-5p and miR-10a-5p, and the upregulation of miR-196a-5p and miR-34c-5p. In carcinosarcoma (CS), lower CSS was associated with the upregulation of miR-184, and the downregulation of let-7b-5p and miR-124. In endometrial stromal sarcomas (ESS), the upregulation of miR-373-3p, miR-372…

Source: CancersCategory: Cancer & Oncology Authors: Tags: Article Source Type: research

ConclusionThese results suggest that ATE-Hex can inhibit human uterine sarcoma cancer cells by inducing apoptosis and increasing the chemosensitivity of the multidrug-resistant human uterine sarcoma cancer cell MES-SA/Dx5 to Dox. Furthermore, the combination of ATE-Hex and Dox could decrease MDR and increase the synergistic effect.Graphical abstract

Source: PhytomedicineCategory: Drugs & Pharmacology Source Type: research

There is concern but no solid evidence that morcellation during laparoscopic or vaginal hysterectomy may cause abdominal spread and thereby impaired prognosis of incidental uterine sarcomas.

Source: European Journal of CancerCategory: Cancer & Oncology Authors: Tags: Original Research Source Type: research

ConclusionsAbout 1 of 4 patients (25%) with single gynecologic cancer recurrence needs IOUS to benefit from MIS for complete secondary cytoreduction.

Conclusions
Our study is the first to compare survival outcomes of HIPEC versus conventional therapies for recurrent US and is suggestive of treatment benefit. Further studies with more patients and longer follow-up to evaluate the role of HIPEC in management of this disease are warranted.

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