(Texas Tech University Health Sciences Center El Paso) A Texas Tech University Health Sciences Center El Paso initiative that is increasing the number of screenings for colorectal cancer across West Texas has caught the eye of the National Cancer Institute.

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Publication date: Available online 27 November 2018Source: Pharmacological ResearchAuthor(s): Fiona Augsburger, Csaba SzaboAbstractHydrogen sulfide (H2S), produced by various endogenous enzyme systems, serves various biological regulatory roles in mammalian cells in health and disease. Over recent years, a new concept emerged in the field of H2S biology, showing that various cancer cells upregulate their endogenous H2S production, and utilize this mediator in autocrine and paracrine manner to stimulate proliferation, bioenergetics and tumor angiogenesis. Initial work identified cystathionine-beta-synthase (CBS) in many tum…

The role of surveillance colonoscopy has long been established: it reduces both the incidence and the mortality of colorectal cancer. We aimed to assess the optimal colonoscopy surveillance interval period for the adenoma patients who underwent an adequate polypectomy at baseline colonoscopy to avoid overuse or underuse of colonoscopy. A retrospective study was carried out on the baseline adenoma patients who had had at least two completed colonoscopy examinations during the years 2000–2013 in the Digestive Endoscopy Center of the First Affiliated Hospital of Kunming Medical University. All the patients had a complet…

The rates of colorectal cancer (CRC) interval surveyed in screen-detected patients using a fecal immunochemical test (FIT) are not negligible. The aim of this study was to assess the effect of interval cancer on outcomes compared with a population with cancer diagnosed after a positive test result. All patients between 50 and 71 years of age, who were residents of the Mantua district, affected by CRC and operated on from 2005 to 2010 were reviewed. Other than patient-related, disease-related, and treatment-related factors and tumor location, this population was differentiated as either participating or not to screening and…

International studies have shown a significant reduction in colorectal cancer (CRC) mortality following the implementation of organized screening programs, given a sufficient participation rate and adequate follow-up. The French national CRC screening program has been generalized since 2008 and targets 18 million men and women aged 50–74 years. Despite broad recommendations, the participation rate remains low (29.8%), questioning the efficiency of the program. A panel of experts was appointed by the French National Cancer Institute to critically examine the place of autonomy and efficiency in CRC screening and propos…

Although rare, cutaneous metastases portend a poor prognosis and are often an indicator of widespread disease. Breast cancer and melanoma are the most common types of cancer that are associated with spread to and within the skin; however, other malignancies, such as lung, colon, head and neck, and hematologic, have been described with a degree of relative frequency. A variety of clinical appearances and syndromes of cutaneous metastases are presented and described in this article. Possible treatment options, including skin-directed therapies and immunotherapies, are also discussed.
PMID: 30497674 [PubMed – in process]

Source: Clinical Lung CancerCategory: Cancer & Oncology Authors: Tags: Hematol Oncol Clin North Am Source Type: research

Contributors : Idan Cohen ; Robert SchneiderSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensThe methylation of residues within histones plays a central role in regulating genome function; however, little is known about the biological importance of a-N-terminal histone methylation. Here we explored the function of the previously uncharacterized a-N methylation of mammalian histone 2B proline 1 (H2BP1me). Genome-wide analyses revealed an enrichment of H2BP1 methylation at certain transposable elements (TEs) and repetitive genomic sequences. We identified a novel histone me…

Source: GEO: Gene Expression OmnibusCategory: Genetics & Stem Cells Tags: Genome binding/occupancy profiling by high throughput sequencing Homo sapiens Source Type: research

ConclusionsThe study underlines the importance and situational variability of personal and social resources for cancer survivors ’ HRQL, even years post-diagnosis. Not only the availability, but also the individual perception and significance of resources should be considered in follow-up cancer care.

Publication date: Available online 1 December 2018Source: Journal of Molecular StructureAuthor(s): Javier Ordóñez-Hernández, Rafael Arcos-Ramos, Héctor García-Ortega, Elizabeth Munguía-Viveros, Margarita Romero-Ávila, Marcos Flores-Alamo, Isabel Gracia-Mora, Francisco Sánchez-Bartéz, Rosa Santillan, Norberto FarfánAbstractA family of pentacoordinated diorganotin(IV) compounds was synthesized and characterized through the advantageous approach of a multicomponent methodology involving the reaction between 4-(diethylamino)salicylaldehyde, dibutyltin oxide …

These diagnostics suggest that direct transport of treatment effects from HORIZON III to the Medicare population is not valid. However, the proposed sampling model might allow valid transport of the treatment effects on longer-term mortality from HORIZON III to the Medicare population treated in clinical practice. See video abstract at, http://links.lww.com/EDE/B435.

Source: EpidemiologyCategory: Epidemiology Tags: Cancer Source Type: research

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