HIGHER doses of statins could prevent 12,000 heart attacks and strokes a year, a study has found.

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Even healthy people who don’t suffer from a cardiovascular disease are prescribed cholesterol-lowering drugs, known as statins, if they meet certain risk criteria. However, for years the use of statins for primary prevention has been hotly debated among experts. “Ultimately, this measure helps to prevent heart attacks or strokes in only a few cases. But all people who take statins are at risk of experiencing the side effects,” says Milo Puhan, professor of epidemiology and public health at the University of Zurich.

Source: World Pharma NewsCategory: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

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Cardiovascular disease (CVD) burden is several-fold higher in patients with chronic kidney disease (CKD). Although statins have been shown to provide significant CVD benefits in both the general population and patients with CKD, this has not translated into survival advantage in patients with advanced CKD or on dialysis. It has been reported that CVD risk continues to escalate as CKD progresses to end-stage kidney disease (ESKD); however, the CVD risk reduction by statins appears to decline as patients’ progress from the early to later stages of CKD. Statins have also been associated with a higher incid…

Conclusion: Intensive atorvastatin therapy in patients with acute ischemic stroke reduces the occurrence of microemboli and inflammation, with no overt adverse events.Eur Neurol 2018;80:163 –170

Conditions:   Stroke, Ischemic;   Atherosclerosis, Cerebral Interventions:   Drug: Atorvastatin Calcium;   Drug: Probucol Sponsor:   General Hospital of Shenyang Military Region Not yet recruiting

Source: ClinicalTrials.govCategory: Research Source Type: clinical trials

For 2018 World Diabetes Day (which is on November 14 of each year, the date of discoverer Frederick Banting’s birth), I avoided much ” celebration ” or even acknowledgement. Its not that I don’t care — indeed, I can remember my involvement of working to get Congressional recognition of the day and helping to persuade the then-UN representative with written letters to that the United States’citizens actually supported the day’s (and month’s) creation way back in the early 1990’s. Prior to that, diabetes wasn’t even acknowledged outside of the medical profession.That said, in many ways, I hate these honorary &quot…

Source: Scott’s Web LogCategory: Endocrinology Tags: 2018 drug prices insulin Source Type: blogs

CONCLUSIONS: Moderate- to high-quality evidence suggests that ezetimibe has modest beneficial effects on the risk of CVD endpoints, primarily driven by a reduction in non-fatal MI and non-fatal stroke, but it has little or no effect on clinical fatal endpoints. The cardiovascular benefit of ezetimibe might involve the reduction of LDL-C, total cholesterol and triglycerides. There is insufficient evidence to determine whether ezetimibe increases the risk of adverse events due to the low and very low quality of the evidence. The evidence for beneficial effects was mainly obtained from individuals with established atheroscler…

Source: Cochrane Database of Systematic ReviewsCategory: General Medicine Authors: Tags: Cochrane Database Syst Rev Source Type: research

(CHICAGO) — Taking fish oil or vitamin D? Big studies give long-awaited answers on who does and does not benefit from these popular nutrients.
Fish oil taken by healthy people, at a dose found in many supplements, showed no clear ability to lower heart or cancer risks. Same for vitamin D.
But higher amounts of a purified, prescription fish oil slashed heart problems and heart-related deaths among people with high triglycerides, a type of fat in the blood, and other risks for heart disease. Doctors cheered the results and said they could suggest a new treatment option for hundreds of thousands of patients like these.

Source: TIME: HealthCategory: Consumer Health News Authors: Tags: Uncategorized onetime Supplements Source Type: news

Omega-3 fatty acids, abundant in fish oil, are known to be good for the heart. Studies have shown that people who eat more fish rich in these fats have lower rates of heart problems and less risk of dying from heart disease compared to those who eat less. Those data have fueled a booming business in over-the-counter fish oil supplements.
In a new study published in the New England Journal of Medicine, and presented at the American Heart Association annual meeting, researchers report that a highly purified version of omega-3 fats, called icosapent ethyl, can lower the risk of a number of heart-related events, including hear…

Source: TIME: HealthCategory: Consumer Health News Authors: Tags: Uncategorized healthytime Heart Disease omega-3 Source Type: news

This study aimed to clarify whether intensive statin therapy resulted in a significant increase in discontinuation early after discharge.
METHODS: This multicenter registry study enrolled consecutive hospitalized patients with ischemic stroke or transient ischemic attack. All the patients were prescribed statin therapy at discharge. Intensity of statin therapy was defined according to the 2013 American College of Cardiology/American Heart Association guideline on the treatment of blood cholesterol. A logistic regression model was used to analyze the association between statin therapy intensity and discontinuation.

Source: Clinical TherapeuticsCategory: Drugs & Pharmacology Authors: Tags: Clin Ther Source Type: research

ConclusionA MACCE was less likely to occur in patients who received a statin ‐ARB than in those who received a statin‐ACEI. Similar trends were seen in cardiovascular mortality and the occurrence of recurrent MI but not stroke. The availability of statin‐ARB fixed‐dose combinations may have contributed to the improved outcomes in the statin‐ARB cohort by reducing p ill burden and improving medication adherence. Further research is warranted to validate our findings and to address whether a particular statin‐ARB combination is more effective than other combinations.



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