For the first time, a systemic therapy has shown clinical activity in a rare eye cancer, metastatic uveal melanoma, for which there is no standard treatment. Medscape Medical News

Source: Medscape Today HeadlinesCategory: Consumer Health News Tags: Hematology-Oncology News Source Type: news

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Conditions:   Cancer;   Melanoma (Skin);   Melanoma, Uveal;   Melanoma, Ocular;   Bladder Cancer;   Mismatch Repair Deficiency;   Microsatellite Instability;   Non-melanoma Skin Cancer Interventions:   Biological: RP1;   Biological: nivolumab Sponsor:   Replimune Inc. Recruiting

Source: ClinicalTrials.govCategory: Research Source Type: clinical trials

Abstract
Uveal melanoma is the most common intraocular primary malignant tumor in adults, and retinoblastoma is the one in children. Current mainstay treatment options include chemotherapy using conventional drugs and enucleation, the total removal of the eyeball. Targeted therapies based on profound understanding of molecular mechanisms of ocular tumors may increase the possibility of preserving the eyeball and the vision. Tyrosine kinases, which modulate signaling pathways regarding various cellular functions including proliferation, differentiation, and attachment, are one of the attractive targets for targeted…

Source: Archives of Pharmacal ResearchCategory: Drugs & Pharmacology Authors: Tags: Arch Pharm Res Source Type: research

AbstractWe appraise the role of screening for distress as part of health psychology assessment of patients newly diagnosed with cancer. We reviewed records of consecutive patients who accepted a health psychologist ’s assessment over 4 years, examining convergence and divergence of the result of screening (whether patients reached threshold as ‘cases’) with the psychologist’s clinical judgment of need for intervention. Of 261 patients, 88 (33.7%) were ‘cases’. Of these, need for psychological inte rvention was identified in 70 (79.5%). Of the 173 (66.3%) ‘non-cases’, nee…

DiscussionChronic inflammation can promote cell proliferation and growth. The use of immunomodulatory drugs is associated with an increased risk of developing melanoma and non-melanoma skin cancer. The two patients described in this report both had long-standing IBD treated with immunomodulatory drugs. It seems reasonable to suggest that these two factors may have promoted the development of uveal melanoma. More studies are warranted to investigate and confirm this possible association.

In this study we comprehensively characterized 488 melanoma cases from 451 non‐CDKN2A/CDK4 families for mutations in 30 established and candidate melanoma susceptibility genes using a custom ‐designed targeted gene panel approach. We identified (likely) pathogenic variants in established melanoma susceptibility genes in 18 families (n=3BAP1, n=15MITF p.E318K; diagnostic yield 4.0%). Among the three identifiedBAP1‐families, there were no reported diagnoses of uveal melanoma or malignant mesothelioma. We additionally identified two potentially deleterious missense variants in the telomere maintenance genesACD andTERF2I…

Source: International Journal of CancerCategory: Cancer & Oncology Authors: Tags: Research Article Source Type: research

BAP1 is a histone deubiquitinase that acts as a tumor and metastasis suppressor associated with disease progression in human cancer. We have used the “Calling Card System” of transposase-directed transposon in…

Source: BMC Medical GenomicsCategory: Genetics & Stem Cells Authors: Tags: Research article Source Type: research

AbstractPurposeUveal melanoma, although a rare form of cancer, is the most common primary malignancy of the eye in adults. Nuclear factor- κB (NF-κB) is a transcription factor that transactivates genes involved in the regulation of cell growth, apoptosis, angiogenesis, and metastasis, but the molecular mechanisms that negatively regulate NF-κB activation are not fully understood. NF-κB can also be activated by DNA damage pathway th rough NEMO protein. Therefore, the objective of this study is to elucidate the role of NEMO/IKKγ protein in uveal melanoma patients.MethodsSeventy-five formalin-fix…

Metastatic uveal melanoma (MUM) has a poor prognosis, with no established standard of care. Delineation of prognostic factors in MUM patients may enable stratified treatment algorithms of stage-specific survival. Overall, 132 MUM patients who presented to a single tertiary institution in Toronto, Canada, over 12 years were identified and data (demographics, clinical status, radiographic images, and laboratory values) were extracted. Associations with systemic first-line treatment outcome 12 weeks after first-line treatment, time to progression (TTP), and overall survival (OS) were explored by univariate and multivariable a…

Source: Melanoma ResearchCategory: Cancer & Oncology Tags: ORIGINAL ARTICLES: Clincal research Source Type: research

CONCLUSIONS: This is the first study to report that THBS2 may play important roles in UM progression and might be a novel prognosis biomarker for UM.
PMID: 30338785 [PubMed – in process]

Condition:   Uveal Melanoma Interventions:   Radiation: Stereotactic Body Radiation Therapy;   Biological: Ziv-Aflibercept Sponsors:   Sidney Kimmel Cancer Center at Thomas Jefferson University;   Regeneron Pharmaceuticals Not yet recruiting

Source: ClinicalTrials.govCategory: Research Source Type: clinical trials



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