‘ Watch and Wait’ Feasible for Some Rectal Cancer Patients


TUESDAY, Nov. 3, 2020 — A ” watch-and-wait ” (WW) strategy may be an option for carefully selected patients who achieve a complete response (CR) to neoadjuvant chemoradiation (nCRT) for rectal adenocarcinoma, according to a study published online…

Related Links:

Neoadjuvant chemotherapy and short-course radiotherapy followed by resection has been gaining recognition in the treatment of rectal cancer. Avelumab is a fully human immunoglobulin that binds Programmed Death…

Source: Radiation OncologyCategory: Cancer & Oncology Authors: Tags: Research Source Type: research

DISCUSSION: In patients with clinical stage II/III rectal cancer who undergo long course neoadjuvant chemo/XRT, perioperative reimaging with CT CAP and/or PET/CT detects new metastases in a small percentage of patients. A multi-institutional, prospective analysis using standardized staging protocols is warranted to better determine the value of preoperative restaging in these patients.
PMID: 32927959 [PubMed – as supplied by publisher]

Source: The American SurgeonCategory: Surgery Authors: Tags: Am Surg Source Type: research

ConclusionThe W&W strategy for low rectal cancer achieved the same oncological outcomes as the traditional strategy while sparing some patients from surgery.

CASE SUMMARY:
A 65-year-old man underwent colonoscopy to evaluate rectal bleeding and was found to have a low rectal mass. Biopsy revealed moderately differentiated microsatellite stable adenocarcinoma. The tumor was palpable at the fingertip in the anterior rectum with the inferior border 5 cm from the anal verge by rigid proctoscopy. CEA was 0.8 ng/mL. CT imaging of the chest, abdomen, and pelvis showed no evidence of distant metastases. MRI confirmed a 5-cm mass with one 8-mm mesorectal lymph node metastasis and no extramural venous invasion. The tumor penetrated the mesorectal fat to a depth of 4&thinsp…

AbstractPurposePatients with locally advanced rectal cancer who achieve pathologic complete response (pCR) following neoadjuvant therapy have better long-term outcomes and could be spared from the perioperative and long-term morbidity of rectal resection. The aim of this study was to identify factors that predict the ability to achieve pCR at completion of conventional neoadjuvant therapy, therefore determining their suitability for non-surgical management.MethodsA retrospective analysis was performed on data obtained from a prospectively maintained colorectal neoplasia database. Patients treated for biopsy-proven primary …

AbstractDiversion colostomy plays a crucial role in the management of carcinoma rectum in low- and middle-income countries as significant number of patients present with partial intestinal obstruction. The aim of this study was to compare laparoscopic and open approaches for fecal diversion done in patients with adenocarcinoma of the rectum as a pretreatment procedure. The primary end point of our study was time to initiation of neoadjuvant chemo radiation. It was a retrospective study that included all patients diagnosed to have carcinoma rectum and underwent a pretreatment fecal diversion between 2012 and 2014. A total o…

CONCLUSION: Multi-visceral resection for advanced colorectal cancer invading into the adjacent organ may be performed with acceptable morbidity and mortality.
PMID: 32674548 [PubMed – as supplied by publisher]

CONCLUSION: The study failed to meet the required 3 pCRs in the first 18 pts. The DFS in this population is encouraging and supports the hypothesis that select pts with rectal cancer may be spared from radiation.
PMID: 32649004 [PubMed – as supplied by publisher]

Source: The OncologistCategory: Cancer & Oncology Authors: Tags: Oncologist Source Type: research

We report 3 cases of mismatch repair-deficient (dMMR) locally advanced adenocarcinoma of the rectum that showed significant response with neoadjuvant immunotherapy-based systemic treatment. The first patient was not eligible for standard therapy because of a history of radiotherapy to the prostate with concurrent comorbidities and therefore received single-agent pembrolizumab. The second patient did not respond to total neoadjuvant chemoradiation and subsequently received combined nivolumab and ipilimumab. The third patient had a known family history of Lynch syndrome and presented with locally advanced rectal cancer and a…

Conclusion:
We suggest a new feasible treatment strategy for the management of synchronous colorectal and prostate cancers.

Source: MedicineCategory: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research



Source link

Get in Touch

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

HCT Deemed More Favorable for MDS That Is High Risk

Hematopoietic stem cell transplant (HCT) treatment of myelodysplastic...

What Is mRNA?: mRNA COVID Vaccine Facts

Two mRNA vaccines from Pfizer and Moderna are nearing final approval, and...

Get in Touch

0FansLike
2,460FollowersFollow
0SubscribersSubscribe

Latest Posts

HCT Deemed More Favorable for MDS That Is High Risk

Hematopoietic stem cell transplant (HCT) treatment of myelodysplastic...

What Is mRNA?: mRNA COVID Vaccine Facts

Two mRNA vaccines from Pfizer and Moderna are nearing final approval, and...

Chicago Tribune – We are currently unavailable in your region

Unfortunately, our website is currently unavailable in most European countries. We are engaged on the issue and committed...

Officials warn of post-Thanksgiving virus spike

Ben Popken14m ago / 1:56 PM UTCTSA screens highest number of travelers since MarchThe Transportation Security Administration said Monday it had screened 1,176,091 passengers...
Supportscreen tag
%d bloggers like this: