Old dogs, new research and the secrets of aging


Dogs go through stages in their life, just as people do, as is obvious to anyone who has watched their stiff-legged companion rouse themselves to go for one more walk.

Poets from Homer to Pablo Neruda have taken notice. As have folk singers and storytellers. Now science is taking a turn, in the hope that research on how dogs age will help us understand how humans age. Like the poets before them, scientists are finding parallels between the two species.

Their research so far shows that dogs are similar to us in important ways, like how they act during adolescence and old age, and what happens in their DNA as they get older. They may be what scientists call a “model” for human aging, a species that we can study to learn more about how we age and perhaps how to age better.

Most recently, researchers in Vienna have found that dogs’ personalities change over time. They seem to mellow in the same way that most humans do. And some dogs —like humans — are just born old, which is to say, relatively steady and mature.

Another paper came to the conclusion that the calculus of seven dog years for every human year isn’t accurate. You must now multiply the natural logarithm of a dog’s age in human years by 16 and then add 31. Is that clear? For example the natural log of 6 is 1.8, roughly, which, multiplied by 16 is about 29, which, plus 31, is 60.

To come to those conclusions researchers sought patterns of chemical changes in DNA, a process called methylation that doesn’t alter genes but does change how active they are.

Lab tests can tell how old a human is just from the pattern of methylation. The same can be done for dogs (although they were not tested in labs but blood was taken with the permission of their owners.) The results will help researchers studying aging in dogs to translate findings to humans.

Scientists are unsure about whether the physical decline seen in aging in dogs and humans, in fact in all mammals, is related to the process of development in earlier life or whether the decline is a different process. The researchers said the pattern of methylation suggested that the same genes may be involved in both processes.

As the Dog Aging Project, which is collecting genetic data from pet dogs, puts it: “Longer, healthier lives for all dogs … and their humans.”

In, 2018 the co-director of the project, Daniel. E. L. Promislow at the University of Washington, Seattle, laid out the reasons dogs make a good animal in which to study aging and get results that will help people. In essence, they suffer similar ailments, such as “obesity, arthritis, hypothyroidism, and diabetes.” And when we imagine that an old dog walks funny for the reasons we do (it hurts), we’re not being anthropomorphic.

Elinor Karlsson at the Broad Institute said, “One of the things that we’re really interested in is figuring out, first of all, whether there are things in the DNA of dogs that you can find that actually explain why some of them live a remarkably long time.” Those findings might be of use in extending healthy aging in people.

 

rn{% endblock %}"},"start":"https://users.startribune.com/placement/1/environment/3/limit-signup-optimizely/start"},{"id":"limit-signup","count":12,"action":"ignore","mute":true,"action_config":{"template":"{% extends "grid" %}rnrn{% block heading_text %}Youu2019ve read your 10 free articles for this 30 day period. Sign up now for local coverage you wonu2019t find anywhere else, special sections and your favorite columnists. StarTribune puts Minnesota and the world right at your fingertips. {% endblock %}rnrn{% block last %}rn{{ parent() }}rn{# limit Krux pixel from https://www.squishlist.com/strib/customshop/328/ #}rnrnrn{% endblock %}"},"start":"https://users.startribune.com/placement/1/environment/3/limit-signup/start"},{"id":"meter-desktop-331","count":10,"action":"ignore","mute":false,"action_config":false,"start":"https://users.startribune.com/placement/1/environment/3/meter-desktop-331/start"},{"id":"PDA991499opt","count":9,"action":"ignore","mute":true,"action_config":false,"start":"https://users.startribune.com/placement/1/environment/3/PDA991499opt/start"},{"id":"limit","count":8,"action":"inject","mute":false,"action_config":{"template":"

rnrnrnrn

rn

rn

rn rn

rn t

rn SUBSCRIBErn Already a subscriber? Log in.rn

rn

All Star Tribune readers without a Digital Access subscription are given a limited number of complimentary articles every 30 days. Once the article limit is reached we ask readers to purchase a subscription including Digital Access to continue reading. Digital Access is included in all multi-day paper home delivery, Sunday + Digital, and Premium Digital Access subscriptions. After the 1 month Premium Digital Access introductory period you will be charged at a rate of $14.99 per month. You can see all subscription options or login to an existing subscription herern

rn rn

rn

rn

rn

rn

rn"},"start":"https://users.startribune.com/placement/1/environment/3/limit/start"},{"id":"nag","count":7,"action":"lightbox","mute":true,"action_config":{"height":null,"width":"630px","redirect_on_close":null,"template":"{% extends "shell" %}rnrn{% block substyles %}rn

rn{% endblock %}rnrn{% block page %}rn{#rnrn{{ limit - count - 1 }}rnrn{{ form.flow_form_open({nextAction: 'firstSlide'}, null, null, '_top') }}rn {{ form.btn('Save Now') }}rn{{ form.flow_form_close() }}rnrn

rnrnrnu2022 rnrnrnrn#}rn

rn

rn You have {{ limit - count - 1 }} articles left

rn

rn rn u00a0u00a0u2022u00a0u00a0rn rn

rn

rn

rn

rn Save More Todayrn

Over 70% off!

rn

rn

rn

rn

99u00a2 for first 4 weeks

rn {{ form.flow_form_open({nextAction: 'firstSlide'}, null, null, '_top') }}rn {{ form.button('Save Now', 'btn nag-btn') }}rn {{ form.flow_form_close() }}rn

rn

rn{% endblock %}rnrn{% block last %}rn{{ parent() }}rnrn{% endblock %}"},"start":"https://users.startribune.com/placement/1/environment/3/nag/start"},{"id":"x","count":4,"action":"ignore","mute":true,"action_config":false,"start":"https://users.startribune.com/placement/1/environment/3/x/start"},{"id":"multi-start","count":3,"action":"fly_in","mute":true,"action_config":{"location":"bottom_left","slide_direction":"bottom","group_id":null,"display_delay":"0","collapse_delay":"10","template":"

rn

rn

rn

rn u00d7rn

rn

rn

From just

rn

$3.79 99u00a2 a week

rn Save nowrn

rn

rn

"},"start":"https://users.startribune.com/placement/1/environment/3/multi-start/start"}]};



Source link

Get in Touch

LEAVE A REPLY

Please enter your comment!
Please enter your name here

Related Articles

Capital Region COVID-19 Tracker for Friday, Nov. 27, by county

Categories: NewsState COVID-19 Tracker numbers for Capital Region counties as of Friday afternoon, Nov. 27. Testing data as of midnight Thursday night.Sources: New York State...

Severely obese to get vaccine before fit and healthy over-60s, guidance confirms

Severely obese people will be given a coronavirus vaccine before healthy over 60s because they are considered more at risk, official guidance...

San Bernardino County breaks coronavirus hospitalization record – Redlands Daily Facts

The number of people hospitalized with COVID-19 in San Bernardino County is higher now than it ever has been, according to data released by...

Get in Touch

0FansLike
2,456FollowersFollow
0SubscribersSubscribe

Latest Posts

Capital Region COVID-19 Tracker for Friday, Nov. 27, by county

Categories: NewsState COVID-19 Tracker numbers for Capital Region counties as of Friday afternoon, Nov. 27. Testing data as of midnight Thursday night.Sources: New York State...

Severely obese to get vaccine before fit and healthy over-60s, guidance confirms

Severely obese people will be given a coronavirus vaccine before healthy over 60s because they are considered more at risk, official guidance...

San Bernardino County breaks coronavirus hospitalization record – Redlands Daily Facts

The number of people hospitalized with COVID-19 in San Bernardino County is higher now than it ever has been, according to data released by...
Supportscreen tag
%d bloggers like this: