Autoinflammatory diseases are caused by genetic mutations in molecules that are involved in regulating the innate immune response-a “hard wired” defense system that evolved to quickly recognize and act against infectious agents and other danger signals produced by our bodies. It is important not to confuse autoinflammatory syndromes with autoimmune diseases, such as: Lupus, Rheumatoid Arthritis and others that are caused by the body’s adaptive immune system developing antibodies to antigens that then attack healthy body tissues. Autoinflammatory diseases are not contagious. When patients are having flares of their disease symptoms they cannot infect anyone, even if they are having a fever, rash, non-infectious conjunctivitis, vomiting, diarrhea or other symptoms that can be confused as an illness. These symptoms are triggered by the autoinflammatory disease,which in most cases are caused by genetic mutations. It is important to distinguish disease flares from infectious diseases.