X-linked agammaglobulinemia (XLA) is a condition that affects the immune system and occurs almost exclusively in males. It is part of a group of disorders called primary immunodeficiencies (or inborn errors of immunity), in which part of the immune system does not function as it should. People with XLA have very few B cells, which are specialized white blood cells that help protect the body against infection. B cells can mature into the cells that produce special proteins called antibodies or immunoglobulins. Antibodies attach to specific foreign particles and germs, marking them for destruction. Individuals with XLA are more susceptible to infections because their body makes very few antibodies.

Children with XLA are usually healthy for the first 1 or 2 months of life because they are protected by antibodies acquired before birth from their mother. After this time, the maternal antibodies are cleared from the body, and the affected child begins to develop recurrent infections. Children with XLA generally take longer to recover from infections, and infections often occur again, even in children who are taking antibiotic medications.

The most common bacterial infections that occur in people with XLA are lung infections (pneumonia and bronchitis), ear infections (otitis), pink eye (conjunctivitis), and sinus infections (sinusitis). Infections that cause chronic diarrhea are also common. Recurrent infections can lead to organ damage. Treatments that replace antibodies can help prevent infections, improving the quality of life for people with XLA.

02xl is your source for accurate and trustworthy information so you can make the best choices for your health and wellness.

PS: Please note that 02xl provides this information for the benefit of the rare disease and overweight community. 02xl is not a medical provider or health care facility and thus can neither diagnose any disease or disorder nor endorse or recommend any specific medical treatments. Patients must rely on the personal and individualized medical advice of their qualified health care professionals before seeking any information related to their particular diagnosis, cure or treatment of a condition or disorder.

Key Proteo Submits De Novo Application to FDA for its First Newborn Screening Kit – Chinook Observer

Key Proteo Submits De Novo Application to FDA for its First Newborn Screening Kit  Chinook Observer Source link

Key Proteo Key Proteo

Update on Immunodeficiency-Associated Vaccine-Derived Polioviruses — Worldwide, July 2018–December 2019

Grace Macklin, MSc1; Ousmane M. Diop, PhD1; Asghar Humayun, MD2; Shohreh Shahmahmoodi, PhD3; Zeinab A. El-Sayed, MD, PhD4; Henda Triki,…

02xl Admin 02xl Admin

Gammaplex 10% Gets FDA Approval

Bio Products Laboratory announced that the Food and Drug Administration (FDA) has approved Gammaplex 10% (immune globulin intravenous , 10%…

Da Hee Han, PharmD Da Hee Han, PharmD
- Advertisement -
Ad imageAd image
Latest Agammaglobulinemia News

Key Proteo Submits De Novo Application to FDA for its First Newborn Screening Kit – Chinook Observer

Key Proteo Submits De Novo Application to FDA for its First Newborn…

Key Proteo Key Proteo

Seattle Children’s Research Institute & Genezen Partner To Advance XLA Gene Therapy

Seattle Children’s Research Institute, the research division of Seattle Children’s Hospital, and…

02xl Admin 02xl Admin

Project 1: Program in Cell Signaling

Selected references Transcriptional signatures of Itk-deficient CD3+, CD4+ and CD8+ T-cells.Blomberg KE,…

02xl Admin 02xl Admin

Two children suffering from rare diseases treated at Delhi hospital

New Delhi, A four-year-old girl suffering from a rare congenital condition, whose…

C. I. Edvard Smith – Karolinska Institutet (KI)

CIE Smith, MD, PhD, Professor, Dept of Laboratory Medicine, Karolinska Institutet (KI)…

Emily Warrender Emily Warrender

Immunodeficiency disorders – UF Health

DefinitionImmunodeficiency disorders occur when the body's immune response is reduced or absent.…

02xl Admin 02xl Admin

FDA Approves Additional Prefilled Syringe Size of Hizentra

The Food and Drug Administration (FDA) has approved a new 50mL/10gm prefilled…

Brian Park, PharmD Brian Park, PharmD

They thought their son had ‘stomach flu’ but he nearly died of sepsis from a rare genetic condition

SINGAPORE - When Ashton Leow had diarrhoea, vomiting and fever on a…

Joyce+Teo Joyce+Teo